Deregulation and Therapeutic Potential of the Hippo Pathway in Cancer

被引：18

作者：

Lin, Kimberly C. ^{[1
,2
]}

Park, Hyun Woo ^{[3
]}

Guan, Kun-Liang ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[3] Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea

来源：

ANNUAL REVIEW OF CANCER BIOLOGY, VOL 2 | 2018年 / 2卷

基金：

新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

Hippo pathway; cancer; YAP; NF2; immunotherapy; EPITHELIAL-MESENCHYMAL TRANSITION; YES-ASSOCIATED PROTEIN; REGULATES CELL-PROLIFERATION; TEAD TRANSCRIPTION FACTORS; AMPK-MEDIATED REGULATION; YAP PATHWAY; SIGNALING-PATHWAY; TUMOR-SUPPRESSOR; CONTACT INHIBITION; UVEAL MELANOMA;

D O I：

10.1146/annurev-cancerbio-030617-050202

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Hippo pathway has drawn increasing interest in the past decade for its role in the regulation of cell growth, differentiation, organ size, and tissue homeostasis. Recent studies have expanded our knowledge of known upstream regulators of the Hippo pathway and have consistently demonstrated that the Hippo pathway is critical for translating cellular cues into transcriptional responses by receiving input from a wide range of upstream signals. Dramatic overgrowth phenotypes upon deregulation of the Hippo pathway have prompted investigation into its role in cancer. Here we provide an overview of the Hippo pathway, our current understanding of its role in tumorigenesis, and potential therapeutics targeting Hippo signaling.

引用

页码：59 / 79

页数：21

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