HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C12:02/C14:03

被引：26

作者：

Lin, Zhansong ^{[1
]}

Kuroki, Kimiko ^{[2
]}

Kuse, Nozomi ^{[1
]}

Sun, Xiaoming ^{[1
]}

Akahoshi, Tomohiro ^{[1
]}

Qi, Ying ^{[3
]}

Chikata, Takayuki ^{[1
]}

Naruto, Takuya ^{[1
]}

Koyanagi, Madoka ^{[1
]}

Murakoshi, Hayato ^{[1
]}

Gatanaga, Hiroyuki ^{[1
,6
]}

Oka, Shinichi ^{[1
,6
]}

Carrington, Mary ^{[3
,4
,5
]}

Maenaka, Katsumi ^{[2
]}

Takiguchi, Masafumi ^{[1
]}

机构：

[1] Kumamoto Univ, Ctr AIDS Res, Chuo Ku, Kumamoto 8600811, Japan

[2] Hokkaido Univ, Fac Pharmaceut Sci, Lab Biomol Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

[3] Leidos Biomed Res Inc, Frederick Natl Labs Canc Res, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA

[4] MIT, MGH, Ragon Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] Harvard, Cambridge, MA 02139 USA

[6] Natl Ctr Global Hlth & Med, AIDS Clin Ctr, Shinjuku Ku, Tokyo 1628655, Japan

来源：

CELL REPORTS | 2016年 / 17卷 / 09期

关键词：

MHC CLASS-I; NATURAL-KILLER-CELLS; CD8(+) T-CELLS; HLA-C; INHIBITORY RECEPTORS; JAPANESE POPULATION; DOWN-REGULATION; VIRUS-INFECTION; SUBTYPE B; BINDING;

D O I：

10.1016/j.celrep.2016.10.075

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Natural killer (NK) cells control viral infection in part through the interaction between killer cell immunoglobulin-like receptors (KIRs) and their human leukocyte antigen (HLA) ligands. We investigated 504 anti-retroviral (ART)-free Japanese patients chronically infected with HIV-1 and identified two KIR/HLA combinations, KIR2DL2/HLA-C*12:02 and KIR2DL2/HLA-C*14:03, that impact suppression of HIV-1 replication. KIR2DL2(+) NK cells suppressed viral replication in HLA-C*14:03(+) or HLA-C*12:02(+) cells to a significantly greater extent than did KIR2DL2(-) NK cells in vitro. Functional analysis showed that the binding between HIV-1-derived peptide and HLA-C*14:03 or HLA-C*12:02 influenced KIR2DL2(+) NK cell activity through reduced expression of the peptide-HLA (pHLA) complex on the cell surface (i.e., reduced KIR2DL2 ligand expression), rather than through reduced binding affinity of KIR2DL2 to the respective pHLA complexes. Thus, KIR2DL2/HLA-C*12:02 and KIR2DL2/HLA-C*14:03 compound genotypes have protective effects on control of HIV-1 through a mechanism involving KIR2DL2-mediated NK cell recognition of virusinfected cells, providing additional understanding of NK cells in HIV-1 infection.

引用

页码：2210 / 2220

页数：11

共 38 条

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HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C*12:02/C*14:03

HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C12:02/C14:03