Cu(I)-catalyzed one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles via nucleophilic displacement and 1,3-dipolar cycloaddition

被引：64
|
作者：
Sreedhar, B [1 ]
Reddy, PS [1 ]
Kumar, NS [1 ]
机构：
[1] Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 18期
关键词：
1,4-disubstittited 1 2,3-triazoles; 1,3-dipolar cycloaddition; PEG; water; CuI;
D O I：
10.1016/j.tetlet.2006.03.007
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method is described for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles in high yields from a variety of Baylis-Hillman acetates and terminal alkynes with sodium azide using CUI as a catalyst, in either water or polyethylene glycol (PEG). This procedure is operationally simple and environmentally benign. Polyethylene glycol (PEG) serves as an efficient reusable solvent with higher efficiency. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3055 / 3058
页数：4
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