An angiotensin-I converting enzyme inhibitor from buckwheat (Fagopyrum esculentum Moench) flour

被引：41
|
作者：
Aoyagi, Y [1 ]
机构：
[1] Kagawa Nutr Univ, Sakado, Saitama 3500288, Japan
来源：
PHYTOCHEMISTRY | 2006年 / 67卷 / 06期
关键词：
buckwheat; Fagopyrum esculentum; polygonaceae; ACE inhibitor; hypotension; non-protein amino acid; phytosiderophore; nicotianamine; 2 ''-hydroxynicotianamine;
D O I：
10.1016/j.phytochem.2005.12.022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A compound that inhibited angiotensin-I converting enzyme (ACE) activity was isolated from buckwheat powder. This compound is thought to be the hydroxy derivative of nicotianamine and its chemical structure is 2"-hydroxynicotianamine. This compound showed a very high inhibitory activity toward ACE, and the IC50 was 0.08 mu M. Only this hydroxy analog was found in buckwheat powder, at about 30 mg/100 g, and no nicotianamine was detected. However, nicotianamine was detected in the buckwheat plant body. 2"-hydroxynicotianamine was also found in other polygonaceous plants. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：618 / 621
页数：4
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