Impaired awareness of hypoglycaemia

被引:2
作者
Amiel, Stephanie A. [1 ]
机构
[1] Kings Coll London, Diabet Res Off, Weston Educ Ctr, 10 Cutcombe Rd, London SE5 9R1, England
来源
BRITISH JOURNAL OF DIABETES | 2022年 / 22卷
关键词
hypoglycaemia; hypoglycaemia awareness; severe hypoglycaemia; INSULIN PUMP; GLUCOSE COUNTERREGULATION; SUBCUTANEOUS INSULIN; TYPE-1; ADULTS; UNAWARENESS; INJECTIONS; RESTORATION; MULTICENTER; FREQUENCY;
D O I
10.15277/bjd.2022.358
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Impaired awareness of hypoglycaemia (IAH), defined either clinically as the loss of subjective awareness of hypoglycaemia before the onset of cognitive impairment or biochemically as the loss of symptom perception until plasma glucose has fallen below 3 mmol/L (54 mg/dl), is the major modifiable risk factor for severe hypoglycaemia in T1DM and possibly in insulin-treated T2DM. This paper tells the story of IAH, its pathogenesis and its implications and the treatment strategies used to address it.
引用
收藏
页码:S26 / S31
页数:6
相关论文
共 52 条
  • [1] A parallel randomised controlled trial of the Hypoglycaemia Awareness Restoration Programme for adults with type 1 diabetes and problematic hypoglycaemia despite optimised self-care (HARPdoc)
    Amiel, Stephanie A.
    Potts, Laura
    Goldsmith, Kimberley
    Jacob, Peter
    Smith, Emma L.
    Gonder-Frederick, Linda
    Heller, Simon
    Toschi, Elena
    Brooks, Augustin
    Kariyawasam, Dulmini
    Choudhary, Pratik
    Stadler, Marietta
    Rogers, Helen
    Kendall, Mike
    Sevdalis, Nick
    Bakolis, Ioannis
    de Zoysa, Nicole
    [J]. NATURE COMMUNICATIONS, 2022, 13 (01)
  • [2] Hypoglycaemia Awareness Restoration Programme for People with Type 1 Diabetes and Problematic Hypoglycaemia Persisting Despite Optimised Self-care (HARPdoc): protocol for a group randomised controlled trial of a novel intervention addressing cognitions
    Amiel, Stephanie A.
    Choudhary, Pratik
    Jacob, Peter
    Smith, Emma Lauretta
    De Zoysa, Nicole
    Gonder-Frederick, Linda
    Kendall, Mike
    Heller, Simon
    Brooks, Augustin
    Toschi, Elena
    Kariyawasam, Dulmini
    Potts, Laura
    Healy, Andy
    Rogers, Helen
    Sevdalis, Nick
    Stadler, Marietta
    Qayyum, Mustabshira
    Bakolis, Ioannis
    Goldsmith, Kimberley
    [J]. BMJ OPEN, 2019, 9 (06):
  • [3] GUIDELINES Diagnosis and management of type 1 diabetes in adults: summary of updated NICE guidance
    Amiel, Stephanie A.
    Lawrence, R. D.
    Pursey, Nancy
    Higgins, Bernard
    Dawoud, Dalia
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2015, 351
  • [4] Fear of hypoglycemia: relationship to hypoglycemic risk and psychological factors
    Anderbro, Therese
    Gonder-Frederick, Linda
    Bolinder, Jan
    Lins, Per-Eric
    Wredling, Regina
    Moberg, Erik
    Lisspers, Jan
    Johansson, Unn-Britt
    [J]. ACTA DIABETOLOGICA, 2015, 52 (03) : 581 - 589
  • [5] BOLLI GB, 1984, NEW ENGL J MED, V310, P1706, DOI 10.1056/NEJM198406283102605
  • [6] Efficacy and safety of suspend-before-low insulin pump technology in hypoglycaemia-prone adults with type 1 diabetes (SMILE): an open-label randomised controlled trial
    Bosi, Emanuele
    Choudhary, Pratik
    de Valk, Harold W.
    Lablanche, Sandrine
    Castaneda, Javier
    de Portu, Simona
    Da Silva, Julien
    Re, Roseline
    Vorrink-de Groot, Linda
    Shin, John
    Kaufman, Francine R.
    Cohen, Ohad
    Bosi, Emanuele
    Laurenzi, Andrea
    Caretto, Amelia
    Choudhary, Pratik
    Slatterly, David
    Henderson-Wilson, Marcia
    Weisnagel, S. John
    Dube, Marie-Christine
    Julien, Valerie-Eve
    Trevisan, Roberto
    Lepore, Giuseppe
    Bellante, Rosalia
    Hramiak, Irene
    Spaic, Tamara
    Driscoll, Marsha
    Borot, Sophie
    Clergeot, Annie
    Khiat, Lamia
    Hammond, Peter
    Ray, Sutapa
    Dinning, Laura
    Tonolo, Giancarlo
    Manconi, Alberto
    Ledda, Maura Serena
    de Valk, Harold
    de Ranitz, Wendela
    Silvius, Bianca
    Wojtusciszyn, Anne
    Farret, Anne
    Vriesendorp, Titia
    Immeker-de Jong, Folkje
    van der Linden, Joke
    Brink, Huguette S.
    Alkemade, Marije
    Schaepelynck-Belicar, Pauline
    Galie, Sebastien
    Treglia, Clemence
    Lablanche, Sandrine
    [J]. LANCET DIABETES & ENDOCRINOLOGY, 2019, 7 (06) : 462 - 472
  • [7] Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations
    Brooks, A. M.
    Walker, N.
    Aldibbiat, A.
    Hughes, S.
    Jones, G.
    de Havilland, J.
    Choudhary, P.
    Huang, G. C.
    Parrott, N.
    McGowan, N. W. A.
    Casey, J.
    Mumford, L.
    Barker, P.
    Burling, K.
    Hovorka, R.
    Walker, M.
    Smith, R. M.
    Forbes, S.
    Rutter, M. K.
    Amiel, S.
    Rosenthal, M. J.
    Johnson, P.
    Shaw, J. A. M.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (12) : 3236 - 3243
  • [8] Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes
    Brown, S. A.
    Kovatchev, B. P.
    Raghinaru, D.
    Lum, J. W.
    Buckingham, B. A.
    Kudva, Y. C.
    Laffel, L. M.
    Levy, C. J.
    Pinsker, J. E.
    Wadwa, R. P.
    Dassau, E.
    Doyle, F. J., III
    Anderson, S. M.
    Church, M. M.
    Dadlani, V
    Ekhlaspour, L.
    Forlenza, G. P.
    Isganaitis, E.
    Lam, D. W.
    Kollman, C.
    Beck, R. W.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (18) : 1707 - 1717
  • [9] Impact of Hybrid Closed Loop Therapy on Hypoglycemia Awareness in Individuals with Type 1 Diabetes and Impaired Hypoglycemia Awareness
    Burckhardt, Marie-Anne
    Abraham, Mary B.
    Dart, Julie
    Smith, Grant J.
    Paramalingam, Nirubasini
    O'Dea, Joanne
    de Bock, Martin
    Davis, Elizabeth A.
    Jones, Timothy W.
    [J]. DIABETES TECHNOLOGY & THERAPEUTICS, 2021, 23 (07) : 482 - 490
  • [10] Sustained Impact of Real-time Continuous Glucose Monitoring in Adults With Type 1 Diabetes on Insulin Pump Therapy: Results After the 24-Month RESCUE Study
    Charleer, Sara
    De Block, Christophe
    Nobels, Frank
    Radermecker, Regis P.
    Lowyck, Ine
    Mullens, Annelies
    Scarniere, Denis
    Spincemaille, Katrien
    Strivay, Marie
    Weber, Eric
    Taes, Youri
    Vercammen, Chris
    Keymeulen, Bart
    Mathieu, Chantal
    Gillard, Pieter
    [J]. DIABETES CARE, 2020, 43 (12) : 3016 - 3023