Leukocyte-Mimicking Stem Cell Delivery via in Situ Coating of Cells with a Bioactive Hyperbranched Polyglycerol

被引：69

作者：

Jeong, Jae Hyun ^{[1
]}

Schmidt, John J. ^{[1
,4
]}

Kohman, Richie E. ^{[2
]}

Zill, Andrew T. ^{[2
]}

DeVolder, Ross J. ^{[1
]}

Smith, Cartney E. ^{[1
]}

Lai, Mei-Hsiu ^{[1
]}

Shkumatov, Artem ^{[1
,4
]}

Jensen, Tor W. ^{[5
]}

Schook, Lawrence G. ^{[3
]}

Zimmerman, Steven C. ^{[2
]}

Kong, Hyunjoon ^{[1
,4
]}

机构：

[1] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA

[4] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA

[5] Univ Illinois, Div Biomed Sci, Urbana, IL 61801 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 24期

基金：

美国国家卫生研究院;

关键词：

Cytology; -; Tissue;

D O I：

10.1021/ja400636d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.

引用

页码：8770 / 8773

页数：4

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