Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions

被引：16

作者：

Andreeva, Tonya D. ^{[1
]}

Hartmann, Hanna ^{[2
]}

Taneva, Stefka G. ^{[1
]}

Krastev, Rumen ^{[2
,3
]}

机构：

[1] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Acad G Bonchev Str,Bl 21, BU-1113 Sofia, Bulgaria

[2] Univ Tubingen NMI, Nat & Med Sci Inst, Dept Biomat, Markwiesenstr 55, D-72770 Reutlingen, Germany

[3] Reutlingen Univ, Fac Appl Chem, Alteburgstr 150, D-72762 Reutlingen, Germany

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 44期

关键词：

POLYELECTROLYTE MULTILAYERS; FILMS; BUILDUP; ADSORPTION; ADHESION; WATER; ION;

D O I：

10.1039/c6tb01638c

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Herein the optimization of the physicochemical properties and surface biocompatibility of polyelectrolyte multilayers of the natural, biocompatible and biodegradable, linear polysaccharides hyaluronan and chitosan by Hofmeister anions was systematically investigated. We demonstrated that there is an interconnection between the bulk and surface properties of HA/Chi multilayers both varying in accordance with the arrangement of the anions in the Hofmeister series. Kosmotropic anions increased the hydration, thickness, micro- and macro-roughness, and hydrophilicity and improved the biocompatibility of the films by reduction (2 orders of magnitude) of the films stiffness and complete anti-thrombogenicity.

引用

页码：7092 / 7100

页数：9

共 43 条

[1] Layer-by-Layer Assembly of Polysaccharide-Based Polyelectrolyte Multilayers: A Spectroscopic Study of Hydrophilicity, Composition, and Ion Pairing [J].