Differential MicroRNA Expression Profiles as Potential Biomarkers for Pancreatic Ductal Adenocarcinoma

被引：8
作者：
Zhu, Y. [1 ]
Wang, J. [2 ]
Wang, F. [3 ]
Yan, Z. [3 ]
Liu, G. [2 ]
Ma, Y. [4 ,5 ]
Zhu, W. [6 ]
Li, Y. [3 ]
Xie, L. [3 ]
Bazhin, A., V [7 ]
Guo, X. [3 ]
机构：
[1] Henan Univ, Dept Oncol, Int Joint Lab Cell Med Engn Henan Prov, Huaihe Hosp, Kaifeng 475000, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 2, Dept Oncol, Zhengzhou 450014, Henan, Peoples R China
[3] Henan Univ, Joint Natl Lab Antibody Drug Engn, Inst Biomed Informat, Med Sch,Dept Prevent Med,Cell Signal Transduct La, Kaifeng 475004, Henan, Peoples R China
[4] Nankai Univ, Coll Pharm, Haihe Educ Pk, Tianjin 300353, Peoples R China
[5] Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk, Tianjin 300353, Peoples R China
[6] Stanford Univ, Dept Anesthesia, Stanford, CA 94305 USA
[7] Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplantat Surg, D-81377 Munich, Germany
来源：
BIOCHEMISTRY-MOSCOW | 2019年 / 84卷 / 05期
基金：
中国国家自然科学基金;
关键词：
pancreatic ductal adenocarcinoma; plasma miRNA; expression profiling; PROGNOSTIC-SIGNIFICANCE; CANCER; APOPTOSIS; RNA; IDENTIFICATION; PROLIFERATION; BIOGENESIS; BLOOD; CELLS; MIRNA;
D O I：
10.1134/S0006297919050122
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) remains a clinical challenge due to its poor prognosis. Therefore, the early diagnosis of PDAC is extremely important for achieving a cure. MicroRNAs (miRNAs) could serve as a potential bio-marker for the early detection and prognosis of PDAC. In this work we analyzed plasma samples from healthy persons and PDAC patients to assess differential miRNA expression profiles by next generation sequencing technology and bioinformatics analysis. In this way, 165 mature miRNAs were found to be significantly deregulated in the patient group, of which 75 and 90 mature miRNAs were up- and down-regulated compared with healthy individuals, respectively. Furthermore, 1029 novel miRNAs were identified. In conclusion, plasma miRNA expression profiles are different between healthy individuals and patients with PDAC. These data provide a possibility for use of miRNA as diagnostic and prognostic biomarkers of PDAC.
引用
收藏
页码：575 / 582
页数：8
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