Stressor-induced alterations in immune response and viral clearance following infection with herpes simplex virus-type 1 in BALB/c and C57B1/6 mice

被引：28
作者：
Brenner, GJ
Moynihan, JA
机构：
[1] UNIV ROCHESTER,SCH MED & DENT,DEPT PSYCHIAT,ROCHESTER,NY 14642
[2] UNIV ROCHESTER,SCH MED & DENT,CTR PSYCHONEUROIMMUNOL RES,ROCHESTER,NY 14642
来源：
BRAIN BEHAVIOR AND IMMUNITY | 1997年 / 11卷 / 01期
关键词：
D O I：
10.1006/brbi.1997.0480
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Extending earlier studies of stress-induced modulation of herpes simplex virus (HSV) infection and immunity, we investigated the effects of electric foot shock (0.3 mA) on cytokine production and immune effector function in response to a nonlethal inoculum of HSV-1 in two strains of inbred mice, C57B1/6 and BALB/c. Increased levels of infectious virus at the site of infection were observed in foot-shocked mice of both strains compared to control mice. The specific pattern of changes in interleukin (IL)-2 and interferon-gamma, as well as IL-4 and IL-10, induced by foot-shock stress differed between the two strains. IgM anti-HSV antibody responses were, however, increased in both strains. (C) 1997 Academic Press.
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页码：9 / 23
页数：15
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