Construction of Eight-Membered Carbocycles through Gold Catalysis with Acetylene-Tethered Silyl Enol Ethers

被引：69

作者：

Iwai, Tomohiro ^{[1
]}

Okochi, Hiori ^{[1
]}

Ito, Hideto ^{[1
]}

Sawamura, Masaya ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Sci, Dept Chem, Sapporo, Hokkaido 0600810, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 15期

关键词：

cyclization; gold; medium-ring compounds; phosphanes; siloxyalkenes; MEDIUM-SIZED RINGS; BULKY END CAPS; 7-EXO-DIG CYCLIZATION; NATURAL-PRODUCTS; TRIETHYNYLPHOSPHINE; COMPLEX; FRAMEWORKS; CHEMISTRY; PROGRESS; LIGANDS;

D O I：

10.1002/anie.201300265

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Semihollow triethynylphosphanes were synthesized and employed as ligands in the gold-catalyzed 8-exo-dig cyclization of acetylene-tethered silyl enol ethers to obtain eight-membered-ring carbocycles (see scheme). The gold-phosphane catalysts promoted either the annulation toward bicyclic structures or the cyclization of acyclic molecules to form nonfused carbocycles. Tf=Trifluoromethylsulfonyl. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4239 / 4242

页数：4

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