Effect of Dosing Cup Size on the Aerosol Performance of High-Dose Carrier-Based Formulations in a Novel Dry Powder Inhaler

被引:3
作者
Yeung, Stewart [1 ,2 ]
Traini, Daniela [1 ,2 ]
Tweedie, Alan [3 ]
Lewis, David [3 ]
Church, Tanya [3 ]
Young, Paul M. [1 ,2 ]
机构
[1] Univ Sydney, Fac Med & Hlth, Resp Technol, Woolcock Inst Med Res, Sydney, NSW 2006, Australia
[2] Univ Sydney, Fac Med & Hlth, Discipline Pharmacol, Sydney, NSW 2006, Australia
[3] Chiesi Ltd, Chippenham, Wilts, England
基金
澳大利亚研究理事会;
关键词
dosing cup size; reservoir-based dry powder inhaler; carrier formulation; impaction forces; aerosol performance; COMPUTATIONAL FLUID-DYNAMICS; PART; DRUG; INHALATION; DESIGN; MIXTURES; DETACHMENT; ADHESION; DELIVERY; CAPSULE;
D O I
10.1016/j.xphs.2018.09.033
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This study investigated how varying the dosing cup size of a novel reservoir dry powder inhaler (DPI) affects the detachment of a micronized active pharmaceutical ingredient from larger carrier particles, and the aerosol performance of a DPI carrier formulation. Three different-sized dosing cups were designed: 3D printed with cup volumes of 16.26 mm(3), 55.99 mm(3), and 133.04 mm(3), and tested with five different carrier type formulations with beclomethasone dipropionate (BDP) concentrations between 1% and 30% (w/w). The morphology of the BDP attached to the carrier was investigated using scanning electron microscopy and the aerosol performance using the Next Generation Impactor. Increasing the volume of the dosing cup led to a reduction of BDP deposition in the Next Generation Impactor preseparator, and an increase in BDP detachment from the carrier was observed, leading to increased aerosol performance. The decreased amount of BDP attached to carrier after aerosolization was attributed to the increased dosing cup void volume. This may enable greater particle-particle and particle-wall collisions, with greater BDP detachment from the carrier and deagglomeration of smaller agglomerates. The dosing cup volume was observed to have significant influence on particle dispersion and the overall aerosol performance of a DPI. (c) 2019 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:949 / 959
页数:11
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