Relapsing-remitting multiple sclerosis: A profile of interleukine-1 gene cluster polymorphisms in Iraqi patients

被引：3
作者：
Al-Naseri, Milad A. S. [1 ]
Salman, Ehab D. [2 ]
Ad'hiah, Ali H. [3 ]
机构：
[1] Iraqi Minist Hlth, Baghdad, Iraq
[2] Univ Baghdad, Coll Sci, Biotechnol Dept, Baghdad, Iraq
[3] Univ Baghdad, Coll Sci, Trop Biol Res Unit, Baghdad, Iraq
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 346卷
关键词：
Relapsing-remitting multiple sclerosis; Intrleukin-1; Single nucleotide polymorphisms; Haplotype; Logistic regression analysis; IL-1 RECEPTOR ANTAGONIST; ASSOCIATION; IL-1-BETA; IMMUNOPATHOLOGY; FAMILY;
D O I：
10.1016/j.jneuroim.2020.577291
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this case-control study, 68 relapsing-remitting multiple sclerosis (RAMS) patients and 133 control were genotyped for ILIA(-889) (rs1800587), IL1B(-511) (rs16944), IL1B(+3962) (rs1143634), IL1R1(pst11970) (rs2234650) and IL1RN(mspa1) (11,100) (rs315952) variants. Sequence-specific-primer-polymerase-chain-reaction was the genotyping method. Logistic regression analysis demonstrated protective effects of ILIB-511, IL1R1(pst11970) and IL1RN(mspa1) (11,100) against MS incidence, while no association was found with ILIA(-889) and IL1B(+3962) variants. Allele frequencies showed no significant gender, medication or expanded disability status scale-associated variation. Haplotype analysis suggested 4.31-fold increased odds for MS in subjects with C-T-C-C-T haplotype of the respective loci. In conclusion, IL-1 gene variants influence MS susceptibility in Iraqi population.
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页数：8
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