New and Xisting regulatory mechanisms of X chromosome inactivation

被引：84
作者：
Jeon, Yesu [1 ]
Sarma, Kavitha [1 ]
Lee, Jeannie T. [1 ]
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Howard Hughes Med Inst,Dept Mol Biol,Dept Genet, Boston, MA 02114 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2012年 / 22卷 / 02期
关键词：
FACULTATIVE HETEROCHROMATIN FORMATION; ES CELL-DIFFERENTIATION; LONG NONCODING RNA; DOSAGE COMPENSATION; SAF-A; CHROMATIN-STRUCTURE; UP-REGULATION; LINKED GENES; STEM-CELLS; MOUSE;
D O I：
10.1016/j.gde.2012.02.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Equalization of X linked gene expression is necessary in mammalian cells due to the presence of two X chromosomes in females and one in males. To achieve this, all female cells inactivate one of the two X chromosomes during development. This process, termed X chromosome inactivation (XCI), is a quintessential epigenetic phenomenon and involves a complex interplay between noncoding RNAs and protein factors. Progress in this area of study has consequently resulted in new approaches to study epigenetics and regulatory RNA function. Here we will discuss recent developments in the field that have advanced our understanding of XCI and its regulatory mechanisms.
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收藏
页码：62 / 71
页数：10
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