Interferon-α (IFNα) neurotoxicity

被引：44

作者：

Fritz-French, Cari ^{[1
]}

Tyor, William ^{[2
,3
]}

机构：

[1] Emory Univ, Immunol & Mol Pathogenesis Grad Program, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA

[3] Atlanta VA Med Ctr, Decatur, GA USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2012年 / 23卷 / 1-2期

关键词：

Interferon-alpha; Neurotoxin; HIV; Cognition; IMMUNODEFICIENCY-VIRUS ENCEPHALITIS; CHRONIC HEPATITIS-C; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CENTRAL-NERVOUS-SYSTEM; ACTIVE ANTIRETROVIRAL THERAPY; HIV-ASSOCIATED DEMENTIA; HIGH-DOSE INTERFERON; SCID MICE; I-INTERFERON; CEREBROSPINAL-FLUID;

D O I：

10.1016/j.cytogfr.2012.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clinical studies indicate that increased central nervous system (CNS) interferon-alpha (IFN alpha) is associated with cognitive dysfunction in a wide variety of conditions. This has perhaps been best studied in HIV-associated neurocognitive disorders (HAND). These findings on IFN alpha neurotoxicity have been corroborated in animal studies. Probably the best demonstration of the neurotoxicity of IFN alpha was through the use of a mouse model of HAND, where it was shown that blocking IFN alpha with neutralizing antibodies prevented behavioral deficits and associated histopathological effects. In vitro studies have demonstrated a dose dependent, detrimental effect of IFN alpha on neuronal dendrites. Development of therapeutics that block IFN alpha may prove to be an effective treatment of HAND and other inflammatory conditions where there is increased CNS IFN alpha. (C) 2012 Elsevier LtdElsevier Ltd. All rights reserved.

引用

页码：7 / 14

页数：8

共 98 条

[1] NEUROPSYCHIATRIC MANIFESTATIONS OF HUMAN-LEUKOCYTE INTERFERON THERAPY IN PATIENTS WITH CANCER [J].

ADAMS, F ;

QUESADA, JR ;

GUTTERMAN, JU .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1984, 252 (07) :938-941

[2] Simian Immunodeficiency Virus Infection in the Brain and Lung Leads to Differential Type I IFN Signaling during Acute Infection [J].

Alammar, Luna ;

Gama, Lucio ;

Clements, Janice E. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (07) :4008-4018

[3] SCID mice with HIV encephalitis develop behavioral abnormalities [J].

Avgeropoulos, N ;

Kelley, B ;

Middaugh, L ;

Arrigo, S ;

Persidsky, Y ;

Gendelman, HE ;

Tyor, WR .

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1998, 18 (01) :13-20

[4] Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus [J].

Blanco, P ;

Palucka, AK ;

Gill, M ;

Pascual, V ;

Banchereau, J .

SCIENCE, 2001, 294 (5546) :1540-1543

[5] ALPHA INTERFERON IN CEREBROSPINAL-FLUID AND SERUM OF PATIENTS WITH CENTRAL-NERVOUS-SYSTEM DISORDERS [J].

BOCKET, L ;

DELFORGE, F ;

WATTRE, P ;

LEMAITRE, JF ;

HOBER, D ;

DEWILDE, A .

REVUE DE MEDECINE INTERNE, 1992, 13 (01) :27-31

[6] Microtubule-associated protein 2 (MAP2) associates with the NMDA receptor and is spatially redistributed within rat hippocampal neurons after oxygen-glucose deprivation [J].

Buddle, M ;

Eberhardt, E ;

Ciminello, LH ;

Levin, T ;

Wing, R ;

DiPasquale, K ;

Raley-Susman, KM .

BRAIN RESEARCH, 2003, 978 (1-2) :38-50

[7] Structural and functional neuropathology in transgenic mice with CNS expression of IFN-α [J].

Campbell, IL ;

Krucker, T ;

Steffensen, S ;

Akwa, Y ;

Powell, HC ;

Lane, TC ;

Carr, DJ ;

Gold, LH ;

Henriksen, SJ ;

Siggins, GR .

BRAIN RESEARCH, 1999, 835 (01) :46-61

[8] Highly active antiretroviral therapy and human immunodeficiency virus encephalitis [J].

Cook, JE ;

Dasgupta, S ;

Middaugh, LD ;

Terry, EC ;

Gorry, PR ;

Wesselingh, SL ;

Tyor, WR .

ANNALS OF NEUROLOGY, 2005, 57 (06) :795-803

[9] Highly active antiretroviral therapy of cognitive dysfunction and neuronal abnormalities in SCID mice with HIV encephalitis [J].

Cook-Easterwood, Jennifer ;

Middaugh, Lawrence D. ;

Griffin, William C., III ;

Khan, Irfan ;

Tyor, William R. .

EXPERIMENTAL NEUROLOGY, 2007, 205 (02) :506-512

[10] Contributions of cloned type I interferon receptor subunits to differential ligand binding [J].

Cutrone, EC ;

Langer, JA .

FEBS LETTERS, 1997, 404 (2-3) :197-202

← 1 2 3 4 5 6 7 8 9 10 →