Multi-modal functional MRI to explore placental function over gestation

被引：64

作者：

Hutter, Jana ^{[1
,2
]}

Slator, Paddy J. ^{[2
]}

Jackson, Laurence ^{[1
,2
]}

Gomes, Ana Dos Santos ^{[1
,2
]}

Ho, Alison ^{[5
]}

Story, Lisa ^{[1
,5
]}

O'Muircheartaigh, Jonathan ^{[1
]}

Teixeira, Rui P. A. G. ^{[1
,2
]}

Chappell, Lucy C. ^{[5
]}

Alexander, Daniel C. ^{[3
,4
]}

Rutherford, Mary A. ^{[1
]}

Hajnal, Joseph V. ^{[1
,2
]}

机构：

[1] Kings Coll London, Ctr Dev Brain, London, England

[2] Kings Coll London, Dept Biomed Engn, London, England

[3] UCL, Ctr Med Image Comp, London, England

[4] UCL, Dept Comp Sci, London, England

[5] Kings Coll London, Womens Hlth Acad Ctr, London, England

来源：

MAGNETIC RESONANCE IN MEDICINE | 2019年 / 81卷 / 02期

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会; 英国惠康基金;

关键词：

placenta; diffusion MRI; relaxometry; development; pregnancy complications; postprocessing; ARTERY DOPPLER ULTRASOUND; NORMAL PREGNANCIES; FETAL-BRAIN; DIFFUSION; PREECLAMPSIA; ASSOCIATION; PREDICTION; PERFUSION;

D O I：

10.1002/mrm.27447

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To investigate, visualize and quantify the physiology of the human placenta in several dimensions - functional, temporal over gestation, and spatial over the whole organ. Methods: Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi-modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre-eclampsia. Results: A multi-faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation. Conclusions: The obtained multi-modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.

引用

页码：1191 / 1204

页数：14

共 55 条

[1] Uterine artery Doppler flow and uteroplacental vascular pathology in normal pregnancies and pregnancies complicated by pre-eclampsia and small for gestational age fetuses [J].

Aardema, MW ;

Oosterhof, H ;

Timmer, A ;

van Rooy, I ;

Aarnoudse, JG .

PLACENTA, 2001, 22 (05) :405-411

[2] Advanced MR imaging of the placenta: Exploring the in utero placenta-brain connection [J].

Andescavage, Nickie Niforatos ;

du Plessis, Adre ;

Limperopoulos, Catherine .

SEMINARS IN PERINATOLOGY, 2015, 39 (02) :113-123

[3]

[Anonymous], BENIRSCHKES PATHOLOG

[4] Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain [J].

Avants, B. B. ;

Epstein, C. L. ;

Grossman, M. ;

Gee, J. C. .

MEDICAL IMAGE ANALYSIS, 2008, 12 (01) :26-41

[5] A new approach to estimate lacunarity of texture images [J].

Backes, Andre Ricardo .

PATTERN RECOGNITION LETTERS, 2013, 34 (13) :1455-1461

[6]

Baschat AA, 2010, J PERINAT MED, V38, P239, DOI 10.1515/jpm.2010.041

[7]

Bibby L, 2012, ARCH DIS CHILD-FETAL, V97

[8] Magnetic resonance imaging of the normal placenta [J].

Blaicher, W ;

Brugger, PC ;

Mittermayer, C ;

Schwindt, J ;

Deutinger, J ;

Bernaschek, G ;

Prayer, D .

EUROPEAN JOURNAL OF RADIOLOGY, 2006, 57 (02) :256-260

[9] Diffusion-weighted MR Imaging of the Placenta in Fetuses with Placental Insufficiency [J].

Bonel, Harald Marcel ;

Stolz, Bernhard ;

Diedrichsen, Lars ;

Frei, Kathrin ;

Saar, Bettina ;

Tutschek, Boris ;

Raio, Luigi ;

Surbek, Daniel ;

Srivastav, Sudesh ;

Nelle, Mathias ;

Slotboom, Johannes ;

Wiest, Roland .

RADIOLOGY, 2010, 257 (03) :810-819

[10] The "Great Obstetrical Syndromes" are associated with disorders of deep placentation [J].

Brosens, Ivo ;

Pijnenborg, Robert ;

Vercruysse, Lisbeth ;

Romero, Roberto .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2011, 204 (03) :193-201

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