Conserved RB functions in development and tumor suppression

被引：40

作者：

Gordon, Gabriel M. ^{[1
]}

Du, Wei ^{[1
]}

机构：

[1] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA

来源：

PROTEIN & CELL | 2011年 / 2卷 / 11期

基金：

美国国家卫生研究院;

关键词：

RB; E2F; Drosophila Rbf; cell cycle; chromatin modification; RETINOBLASTOMA GENE-PRODUCT; DEPENDENT KINASE INHIBITOR; CELL-CYCLE PROGRESSION; PROMOTES GENOMIC INSTABILITY; ONCOGENE-INDUCED SENESCENCE; E2F TARGET GENES; DNA-DAMAGE; PREMATURE SENESCENCE; DROSOPHILA EMBRYOGENESIS; TERMINAL DIFFERENTIATION;

D O I：

10.1007/s13238-011-1117-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The variety of human cancers in which the retinoblastoma protein pRb is inactivated reflects both its broad importance for tumor suppression and its multitude of cellular functions. Accumulating evidence indicates that pRb contributes to a diversity of cellular functions, including cell proliferation, differentiation, cell death, and genome stability. pRb performs these diverse functions through the formation of large complexes that include E2F transcription factors and chromatin regulators. In this review we will discuss some of the recent advances made in understanding the structure and function of pRb as they relate to tumor suppression, and highlight research using Drosophila melanogaster that reveals important, evolutionarily conserved functions of the RB family.

引用

页码：864 / 878

页数：15

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