Defective B-l cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice

被引：186
作者：
Yoshida, T
Ikuta, K
Sugaya, H
Maki, K
Takagi, M
Kanazawa, H
Sunaga, S
Kinashi, T
Yoshimura, K
Miyazaki, J
Takaki, S
Takatsu, K
机构：
[1] UNIV TOKYO, FAC MED, DEPT STEM CELL REGULAT, INST MED SCI, TOKYO 108, JAPAN
[2] UNIV TOKYO, FAC MED, DEPT DIS RELATED GENE REGULAT RES SANDOZ, MINATO KU, TOKYO 108, JAPAN
[3] AKITA UNIV, SCH MED, DEPT PARASITOL, AKITA 010, JAPAN
来源：
IMMUNITY | 1996年 / 4卷 / 05期
关键词：
D O I：
10.1016/S1074-7613(00)80414-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We generated interleukin-5 receptor alpha chain (IL-5R alpha)-deficient (IL-5R alpha(-/-)) mice by gene targeting. The IL-5R alpha(-/-) mice showed decreased numbers of B-l cells concomitant with low serum concentrations of IgM and IgG3. They showed no IL-5-induced enhancement of B cell responses to T-independent antigens. The number of alpha beta T cell receptor-positive thymocytes tended to decrease in 3-week-old IL-5R alpha(-/-) mice, returning to normal by 6 weeks of age. The IL-5R alpha(-/-) mice produced basal levels of eosinophils, while their bone marrow cells failed to form eosinophilic colonies in response to IL-5. Impaired eosinophilopoiesis in IL-5R alpha(-/-) mice enhanced the survival of Angiostrongylus cantonensis. These results indicate that IL-5-induced eosinophils serve as potent effector cells in the killing of Angiostrongylus cantonensis in mice.
引用
收藏
页码：483 / 494
页数：12
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