U-shaped association between serum albumin and pediatric intensive care unit mortality in critically ill children

被引：3

作者：

Zhang, Xuepeng ^{[1
,2
,3
]}

Zhang, Lifan ^{[4
]}

Wei, Canzheng ^{[2
,5
]}

Feng, Liwei ^{[1
]}

Yang, Juqin ^{[6
]}

Zhang, Geng ^{[2
]}

Lu, Guoyan ^{[7
]}

Gui, Xiying ^{[8
]}

Zhou, Yue ^{[2
]}

Yang, Kaiying ^{[1
]}

Zhou, Jiangyuan ^{[1
]}

Zhou, Xinle ^{[9
]}

Wang, Ruoran ^{[2
]}

Chen, Siyuan ^{[2
]}

Ji, Yi ^{[1
]}

机构：

[1] Sichuan Univ, Dept Pediat Surg, West China Hosp, Chengdu, Peoples R China

[2] Sichuan Univ, Dept Crit Care Med, West China Hosp, Chengdu, Peoples R China

[3] Univ Elect Sci & Technol China, Mianyang Cent Hosp, Dept Crit Care Med, Mianyang, Peoples R China

[4] Sichuan Univ, West China Sch Med, Chengdu, Peoples R China

[5] Shandong First Med Univ, Dept Crit Care Med, Affiliated Hosp 2, Tai An, Peoples R China

[6] Sichuan Univ, West China Hosp, Biobank, Chengdu, Peoples R China

[7] Sichuan Univ, West China Womens & Childrens Hosp, Dept Pediat Crit Care Med, Chengdu, Peoples R China

[8] Peoples Hosp Tibet Autonomous Reg, Dept Crit Care Med, Lhasa, Peoples R China

[9] Sichuan Prov Matern & Child Hlth Care Hosp, Dept Pediat Crit Care Med, Chengdu, Peoples R China

来源：

FRONTIERS IN NUTRITION | 2022年 / 9卷

关键词：

children; albumin; critical care; restricted cubic spline; mortality; CLINICAL-OUTCOMES; PREDICTOR; INTERVENTION; ADMISSION; SURVIVAL; LENGTH; LEVEL; STAY;

D O I：

10.3389/fnut.2022.931599

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

IntroductionThe detailed association between albumin levels and mortality has not been studied in critically ill children. The aim of this study was to reveal an association between albumin levels in detail and mortality in critically ill children. Materials and methodsWe retrospectively collected data from children admitted to four pediatric intensive care units (PICUs) in China between January 2015 and October 2020. Restricted cubic spline curves based on logistic regression models were generated to evaluate the detailed associations between serum albumin levels and PICU mortality. Threshold effect analysis was performed using two piecewise regression models. ResultsThe study included 9,123 children. The overall mortality was 5.3%. The detailed association between serum albumin levels and the risk of mortality followed a U-shape. The risk of mortality decreased with increasing serum albumin levels (OR = 0.919; 95% CI: 0.886, 0.954) in children with serum albumin levels < 43.2 g/L and increased with increasing serum albumin levels (OR = 1.174; 95% CI: 1.044, 1.316) in children with serum albumin levels >= 43.2 g/L. ConclusionThere was a U-shaped association between serum albumin levels and mortality in critically ill children in the PICU.

引用

页数：9

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