Effect of denervation on knee joint function and pain in patients with knee osteoarthritis and cartilage injuries

被引：0

作者：

Wang, Shuo ^{[1
,2
,3
]}

Jiang, Ye ^{[4
]}

Liang, Luoyin ^{[5
]}

Zhong, Xin ^{[6
]}

Cheung, Hoi Yan ^{[7
]}

Zhou, Jingjie ^{[1
,2
,3
]}

机构：

[1] Xuzhou Cent Hosp, 10 Kuizhong Lane, Xuzhou 221000, Jiangsu, Peoples R China

[2] Xuzhou Med Univ, Xuzhou Clin Sch, 10 Kuizhong Lane, Xuzhou 221000, Jiangsu, Peoples R China

[3] Xuzhou Med Univ, Affiliated Xuzhou Rehabil Hosp, 10 Kuizhong Lane, Xuzhou 221000, Jiangsu, Peoples R China

[4] Xuzhou Med Univ, Affiliated Lianyungang Hosp, Dept Neurol Rehabil, Lianyungang, Peoples R China

[5] Suining Cent Hosp, Suining, Peoples R China

[6] Nanchang Univ, Fuzhou Med Coll, Fuzhou, Peoples R China

[7] Jinan Univ, Sch Tradit Chinese Med, Jinan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2020年 / 13卷 / 08期

关键词：

Knee osteoarthritis; cartilage injury; denervation; knee joint function; pain; synovial fluid; AAHKS CLINICAL-RESEARCH; PLATELET-RICH PLASMA; SURGICAL-MANAGEMENT; ASSOCIATION; GUIDELINES; EFFICACY; CRITERIA; COSTS; HIP;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: To investigate the effect of denervation on knee joint function and pain in patients with knee osteoarthritis and cartilage injuries. Methods: In total, 93 patients with knee osteoarthritis and cartilage injuries hospitalized from January 2018 to January 2019 were involved in this study and divided randomly into a control group (n=46) and an observation group (n=47). The control group was treated with arthroscopic debridement while the observation group received denervation on top of arthroscopic debridement. The therapeutic effects before and after treatment were statistically evaluated between the two groups. Clinical manifestations including knee joint function, pain in knee joints, levels of IL-1 beta, TNF-alpha and FGF-21 in serum and synovial fluid, and complications were observed. Results: The observation group showed an overall response rate of 87.23%, significantly higher than 69.56% of the control group (P < 0.05). After operation, both groups had increased scores of knee joint function, and hip joint function was significantly higher in the observation group at 1, 3 and 6 months after operation (P < 0.05); the pain scores decreased in both groups and the observation group was significantly lower at 1, 3 and 6 months after operation (P < 0.05). Serum IL-1 beta and TNF-alpha as well as the levels of IL-1 beta, TNF-alpha and FGF-21 in the synovial fluid decreased in the two groups and were significantly lower in the observation group at 1 month after operation (P < 0.05); there was no significant difference in the incidence of complications between the two groups (P > 0.05). Conclusion: Denervation is of high application value in improving the knee joint function, alleviating postoperative pain, and reducing the levels of IL-1 beta, TNF-alpha, and FGF-21 in patients with knee osteoarthritis and cartilage injuries.

引用

页码：5991 / 5997

页数：7

共 25 条

[1] Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis [J].

Alshenibr, Weam ;

Tashkandi, Mustafa M. ;

Alsaqer, Saqer F. ;

Alkheriji, Yazeed ;

Wise, Amelia ;

Fulzele, Sadanand ;

Mehra, Pushkar ;

Goldring, Mary B. ;

Gerstenfeld, Louis C. ;

Bais, Manish V. .

ARTHRITIS RESEARCH & THERAPY, 2017, 19

[2] Letter to the Editor on "The AAHKS Clinical Research Award: What Are the Costs of Knee Osteoarthritis in the Year Prior to Total Knee Arthroplasty?" [J].

Altman, Roy D. .

JOURNAL OF ARTHROPLASTY, 2018, 33 (01) :305-307

[3]

Bar-Or David, 2017, Semin Arthritis Rheum, V46, pe20, DOI 10.1016/j.semarthrit.2016.08.010

[4] The AAHKS Clinical Research Award: What Are the Costs of Knee Osteoarthritis in the Year Prior to Total Knee Arthroplasty? [J].

Bedard, Nicholas A. ;

Dowdle, Spencer B. ;

Anthony, Christopher A. ;

DeMik, David E. ;

McHugh, Michael A. ;

Bozic, Kevin J. ;

Callaghan, John J. .

JOURNAL OF ARTHROPLASTY, 2017, 32 (09) :S8-+

[5] The UK NICE 2014 Guidelines for Osteoarthritis of the Knee: Lessons Learned in a Narrative Review Addressing Inadvertent Limitations and Bias [J].

Birch, Stephen ;

Lee, Myeong Soo ;

Robinson, Nicola ;

Alraek, Terje .

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2017, 23 (04) :242-246

[6] Changes in biomechanical risk factors for knee osteoarthritis and their association with 5-year clinically important improvement after limb realignment surgery [J].

Birmingham, T. B. ;

Moyer, R. ;

Leitch, K. ;

Chesworth, B. ;

Bryant, D. ;

Willits, K. ;

Litchfield, R. ;

Fowler, P. J. ;

Giffin, J. R. .

OSTEOARTHRITIS AND CARTILAGE, 2017, 25 (12) :1999-2006

[7]

Boutefnouchet Tarek, 2017, Knee Surg Relat Res, V29, P129, DOI 10.5792/ksrr.16.061

[8] Skeletal muscle vitamin D in patients with end stage osteoarthritis of the knee [J].

Brennan-Speranza, Tara C. ;

Mor, David ;

Mason, Rebecca S. ;

Bartlett, John R. ;

Duque, Gustavo ;

Levinger, Itamar ;

Levinger, Pazit .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2017, 173 :180-184

[9] Compliance With the AAOS Guidelines for Treatment of Osteoarthritis of the Knee: A Survey of the American Association of Hip and Knee Surgeons [J].

Carlson, Victor Rex ;

Ong, Alvin Chua ;

Orozco, Fabio Ramiro ;

Hernandez, Victor Hugo ;

Lutz, Rex William ;

Post, Zachary Douglas .

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 2018, 26 (03) :103-107

[10] LMWF-5A for the Treatment of Severe Osteoarthritis of the Knee: Integrated Analysis of Safety and Efficacy [J].

Cole, Brian ;

McGrath, Brian ;

Salottolo, Kristin ;

Bar-Or, David .

ORTHOPEDICS, 2018, 41 (01) :E77-E83

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