Alcohol-induced alterations in dopamine modulation of prefrontal activity

被引：54

作者：

Trantham-Davidson, Heather ^{[1
]}

Chandler, L. Judson ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

来源：

ALCOHOL | 2015年 / 49卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Dopamine; Prefrontal cortex; Alcohol; Cognition; VENTRAL TEGMENTAL AREA; MU-OPIOID RECEPTORS; NUCLEUS-ACCUMBENS; EXECUTIVE FUNCTIONS; SYNAPTIC-TRANSMISSION; CORTICAL DOPAMINE; PYRAMIDAL NEURONS; FEAR EXTINCTION; CHRONIC ETHANOL; WORKING-MEMORY;

D O I：

10.1016/j.alcohol.2015.09.001

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Long-term alcohol use leads to persistent cognitive deficits that may be associated with maladaptive changes in the neurocircuitry that mediates executive functions. Impairments caused by these changes can persist well into abstinence and have a negative impact on quality of life and job performance, and can increase the probability of relapse. Many of the changes that affect cognitive function appear to involve dysregulation of the mesocortical dopamine system. This includes changes in dopamine release and alterations in dopamine receptor expression and function in the medial prefrontal cortex (PFC). This review summarizes the cellular effects of acute and chronic ethanol exposure on dopamine release and dopamine receptor function in the PFC with the goal of providing greater understanding of the effects of alcohol-use disorders on the dopamine system and how this relates to deficits in the executive function of the PFC. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：773 / 779

页数：7

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