Synthesis and anti-inflammatory activity of three nitro chalcones

被引：53

作者：

Gomez-Rivera, Abraham ^{[1
]}

Aguilar-Mariscal, Hidemi ^{[2
]}

Romero-Ceronio, Nancy ^{[1
]}

Roa-de la Fuente, Luis F. ^{[1
]}

Lobato-Garcia, Carlos E. ^{[1
]}

机构：

[1] Div Acad Ciencias Basicas, Tabasco 86690, Mexico

[2] Div Acad Ciencias Salud, Villahermosa 86150, Mexico

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 20期

关键词：

Synthesis; Anti-inflammatory; Nitro chalcone; Carrageenan induced edema; DERIVATIVES;

D O I：

10.1016/j.bmcl.2013.08.061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their antiinflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72-73% yields in approximately 2 h. The three structures were evaluated on biological activity at dose of 200 mg/kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

引用

页码：5519 / 5522

页数：4

共 14 条

[1]

Aguilar H., 2006, P W PHARM SOC, V49, P45

[2]

Aguilar H., 2008, THESIS IPN

[3] Aryl azoles with neuroprotective activity - Parallel synthesis and attempts at target identification [J].

Cocconcelli, Giuseppe ;

Diodato, Enrica ;

Caricasole, Andrea ;

Gaviraghi, Giovanni ;

Genesio, Eva ;

Ghiron, Chiara ;

Magnoni, Letizia ;

Pecchioli, Elena ;

Plazzi, Pier Vincenzo ;

Terstappen, Georg C. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (04) :2043-2052

[4] Studies on the anti-oedematogenic properties of a fraction rich in lonchocarpin and derricin isolated from Lonchocarpus sericeus [J].

Fontenele, J. B. ;

Leal, L. K. A. M. ;

Felix, F. H. C. ;

Silveira, E. R. ;

Viana, G. S. B. .

NATURAL PRODUCT RESEARCH, 2009, 23 (18) :1677-1688

[5] Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones [J].

Konduru, Naveen Kumar ;

Dey, Sunita ;

Sajid, Mohammad ;

Owais, Mohammad ;

Ahmed, Naseem .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 59 :23-30

[6] Synthesis and Anti-Inflammatory Activity of Chalcones and Related Mannich Bases [J].

Maria, Kouskoura ;

Dimitra, Hadjipavlou-Litina ;

Maria, Giakoumakou .

MEDICINAL CHEMISTRY, 2008, 4 (06) :586-596

[7]

Najafian M, 2010, ACTA BIOCHIM POL, V57, P553

[8] Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents [J].

Peng, Fei ;

Wang, Guangcheng ;

Li, Xiuxia ;

Cao, Dong ;

Yang, Zhuang ;

Ma, Liang ;

Ye, Haoyu ;

Liang, Xiaolin ;

Ran, Yan ;

Chen, Jinying ;

Qiu, Jingxiang ;

Xie, Caifeng ;

Deng, Chongyang ;

Xiang, Mingli ;

Peng, Aihua ;

Wei, Yuquan ;

Chen, Lijuan .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 54 :272-280

[9]

Perozo E., 2006, CAT TODAY, V4413, P1

[10] Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells [J].

Shibuya, Akiko ;

Onda, Kenji ;

Kawahara, Hirofumi ;

Uchiyama, Yuka ;

Nakayama, Hiroko ;

Omi, Takamasa ;

Nagaoka, Masayoshi ;

Matsui, Hirofumi ;

Hirano, Toshihiko .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 398 (03) :581-584

← 1 2 →