An efficient one-pot protocol for regioselective synthesis of 3-aryl-6,8-dialkyl-7-thioxo-7,8-dihydropyrimido[4,5-c] pyridazine-5(6H)-ones

被引：10
作者：
Khalafy, Jabbar [1 ]
Rimaz, Mehdi [2 ]
Rabiei, Hossein [1 ]
Panahi, Leila [1 ]
机构：
[1] Urmia Univ, Dept Chem, Orumiyeh, Iran
[2] Payame Noor Univ, Dept Chem, Tehran, Iran
来源：
JOURNAL OF SULFUR CHEMISTRY | 2013年 / 34卷 / 04期
关键词：
pyrimido[4; 5-c]pyridazines; regioselective; one-pot; arylglyoxal; thiobarbituric acid; 3 COMPONENT SYNTHESIS; MONOAMINE-OXIDASE; MULTICOMPONENT REACTIONS; PYRIDAZINE DERIVATIVES; 3-COMPONENT SYNTHESIS; ORGANIC-SYNTHESIS; DOMINO REACTIONS; SULFUR ANALOGS; INHIBITORS; ACID;
D O I：
10.1080/17415993.2012.745126
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 3-aryl-6,8-dialkyl-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazine-5(6H)-one derivatives have been regioselectively synthesized via the one-pot three-component reaction of 1,3-dimethylthiobarbituric acid and 1,3-diethylthiobarbituric acid with various arylglyoxals in the presence of hydrazinium dihydrochloride in warm ethanol. These new substituted pyrimidopyridazines may be potential monoamine oxidase inhibitors. [GRAPHICS] .
引用
收藏
页码：395 / 406
页数：12
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