The CD40/CD4OL system: A new therapeutic target for disease

被引：69
作者：
Zhang, Bikui [1 ]
Wu, Tian [1 ,2 ]
Chen, Min [1 ]
Zhou, Yulu [1 ]
Yi, Dongyang [1 ]
Guo, Ren [1 ]
机构：
[1] Cent S Univ, Dept Pharm, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China
[2] Cent S Univ, Dept Pharmaceut, Coll Pharm, Changsha 410013, Hunan, Peoples R China
来源：
IMMUNOLOGY LETTERS | 2013年 / 153卷 / 1-2期
关键词：
CD40/CD4OL; Monoclonal antibodies (mAbs); Statins; Clopidogrel; SGN-40; SOLUBLE CD40 LIGAND; ANTI-CD40; MONOCLONAL-ANTIBODY; ACUTE CORONARY SYNDROMES; VASCULAR ENDOTHELIAL-CELLS; HYPER-IGM SYNDROME; DENDRITIC CELLS; UNSTABLE ANGINA; IN-VITRO; B-CELLS; ACTIVATION;
D O I：
10.1016/j.imlet.2013.07.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of CD40/CD40 ligand (CD40L) interactions in atherothrombosis, in the response of the immune system to pathogens and in thrombosis is now widely accepted. A role for CD40-CD40L interactions has been identified in atherosclerosis (AS), and such interactions are known to destabilize atherosclerotic plaques by inducing the expression of cytokines, chemokines, growth factors, matrix metalloproteinases and pro-coagulant factors. CD40/CD40L interactions have also been implicated in immune system disorders. Recent studies have suggested that CD40/CD40L interactions regulate oxidative stress and affect various signaling pathways in both the immunological and the cardiovascular systems. Here, we discuss the current drugs that target the CD40/CD40Lsystem, as understanding the roles and regulations of CD40/CD40L-mediated signal pathways by these drugs could facilitate the development of therapeutics that target diverse diseases. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：58 / 61
页数：4
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