No association between MspI allele of the ADRA2A polymorphism and ADHD: meta-analysis of family-based studies

被引：6

作者：

Shiffrin, Nina D. ^{[1
]}

Gruber, June ^{[1
]}

Glatt, Stephen J. ^{[2
,3
]}

Faraone, Stephen V. ^{[2
,3
]}

机构：

[1] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

[2] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA

[3] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA

来源：

PSYCHIATRIC GENETICS | 2013年 / 23卷 / 04期

关键词：

attention-deficit hyperactivity disorder; ADRA2A; adrenergic 2A receptor; association; gene; meta-analysis; polymorphism; DEFICIT-HYPERACTIVITY-DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ALPHA-2A ADRENERGIC-RECEPTOR; CANDIDATE GENES; DISABILITIES; INVOLVEMENT; ADOLESCENTS; SYMPTOMS; CHILDREN; LINKAGE;

D O I：

10.1097/YPG.0b013e3283631509

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

There is evidence for a genetic contribution to attention-deficit hyperactivity disorder (ADHD), although no candidate genes have attained genome-wide significance to date. Given that the noradrenergic system has been implicated in ADHD, the gene for the 2-adrenergic receptor (ADRA2A) has been hypothesized to contribute to the pathogenesis of ADHD. The present investigation reports results from a meta-analysis of family-based studies that did not find a significant association between the MspI polymorphism of the ADRA2A gene and ADHD.

引用

页码：174 / 175

页数：2

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