InterPro in 2019: improving coverage, classification and access to protein sequence annotations

被引：1057

作者：

Mitchell, Alex L. ^{[1
]}

Attwood, Teresa K. ^{[2
]}

Babbitt, Patricia C. ^{[3
]}

Blum, Matthias ^{[1
]}

Bork, Peer ^{[4
]}

Bridge, Alan ^{[5
]}

Brown, Shoshana D. ^{[3
]}

Chang, Hsin-Yu ^{[1
]}

El-Gebali, Sara ^{[1
]}

Fraser, Matthew I. ^{[1
]}

Gough, Julian ^{[6
]}

Haft, David R. ^{[7
]}

Huang, Hongzhan ^{[8
]}

Letunic, Ivica ^{[9
]}

Lopez, Rodrigo ^{[1
]}

Luciani, Aurelien ^{[1
]}

Madeira, Fabio ^{[1
]}

Marchler-Bauer, Aron ^{[10
]}

Mi, Huaiyu ^{[11
]}

Natale, Darren A. ^{[12
]}

Necci, Marco ^{[13
,14
,15
]}

Nuka, Gift ^{[1
]}

Orengo, Christine ^{[16
]}

Pandurangan, Arun P. ^{[6
]}

Paysan-Lafosse, Typhaine ^{[1
]}

Pesseat, Sebastien ^{[1
]}

Potter, Simon C. ^{[1
]}

Qureshi, Matloob A. ^{[1
]}

Rawlings, Neil D. ^{[1
]}

Redaschi, Nicole ^{[5
]}

Richardson, Lorna J. ^{[1
]}

Rivoire, Catherine ^{[5
]}

Salazar, Gustavo A. ^{[1
]}

Sangrador-Vegas, Amaia ^{[1
]}

Sigrist, Christian J. A. ^{[5
]}

Sillitoe, Ian ^{[16
]}

Sutton, Granger G. ^{[7
]}

Thanki, Narmada ^{[10
]}

Thomas, Paul D. ^{[11
]}

Tosatto, Silvio C. E. ^{[13
]}

Yong, Siew-Yit ^{[1
]}

Finn, Robert D. ^{[1
]}

机构：

[1] EMBL EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SD, England

[2] Univ Manchester, Sch Comp Sci, Manchester M13 9PL, Lancs, England

[3] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[4] European Mol Biol Lab, Struct & Computat Biol Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany

[5] CMU, SIB Swiss Inst Bioinformat, Swiss Prot Grp, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland

[6] MRC, Lab Mol Biol, Francis Crick Ave,Cambridge Biomed Campus, Cambridge CB2 0QH, England

[7] JCVI, 9605 Med Ctr Dr,Suite 150, Rockville, MD 20850 USA

[8] Univ Delaware, Ctr Bioinformat & Computat Biol, Newark, DE USA

[9] Biobyte Solut GmbH, Bothestr 142, D-69126 Heidelberg, Germany

[10] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH Bldg,38A,8600 Rockville Pike, Bethesda, MD 20894 USA

[11] Univ Southern Calif, Dept Prevent Med, Div Bioinformat, Los Angeles, CA 90033 USA

[12] Georgetown Univ, Med Ctr, Protein Informat Resource, Washington, DC 20007 USA

[13] Univ Padua, Dept Biomed Sci, Via U Bassi 58b, I-35131 Padua, Italy

[14] Univ Udine, Dept Agr Sci, Via Palladio 8, I-33100 Udine, Italy

[15] Fdn Edmund Mach, Via E Mach 1, I-38010 San Michele All Adige, Italy

[16] UCL, Struct & Mol Biol, Darwin Bldg, London WC1E 6BT, England

来源：

NUCLEIC ACIDS RESEARCH | 2019年 / 47卷 / D1期

基金：

英国生物技术与生命科学研究理事会; 美国国家科学基金会; 英国惠康基金; 美国国家卫生研究院;

关键词：

FAMILY CLASSIFICATION; GENE ONTOLOGY; DATABASE; PREDICTION; TOPOLOGY; TOOL;

D O I：

10.1093/nar/gky1100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The InterPro database (http://www.ebi.ac.uk/interpro/) classifies protein sequences into families and predicts the presence of functionally important domains and sites. Here, we report recent developments with InterPro (version 70.0) and its associated software, including an 18% growth in the size of the database in terms on new InterPro entries, updates to content, the inclusion of an additional entry type, refined modelling of discontinuous domains, and the development of a new programmatic interface and website. These developments extend and enrich the information provided by InterPro, and provide greater flexibility in terms of data access. We also show that InterPro's sequence coverage has kept pace with the growth of UniProtKB, and discuss how our evaluation of residue coverage may help guide future curation activities.

引用

页码：D351 / D360

页数：10

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