Universal tumor screening for lynch syndrome: perspectives of patients regarding willingness and informed consent

被引：5
作者：
Subramonian, Anusree [1 ]
Smith, Doug
Dicks, Elizabeth [1 ]
Dawson, Lesa [2 ,3 ]
Borgaonkar, Mark [4 ]
Etchegary, Holly [1 ]
机构：
[1] Mem Univ, Fac Med, Clin Epidemiol, St John, NF, Canada
[2] Mem Univ, Fac Med, Gynecol Oncol Womens Hlth & Genet, St John, NF, Canada
[3] Eastern Hlth, Womens Hlth & Genet, St John, NF, Canada
[4] Mem Univ, Fac Med, Gastroenterol, St John, NF, Canada
来源：
PERSONALIZED MEDICINE | 2020年 / 17卷 / 05期
关键词：
colorectal cancer; lynch syndrome; patient oriented research; reflex testing; universal tumor screening; REVISED BETHESDA GUIDELINES; GENETIC TESTING STRATEGIES; COLORECTAL-CANCER SYNDROME; MICROSATELLITE INSTABILITY; FAMILY COMMUNICATION; REDUCING MORBIDITY; COST-EFFECTIVENESS; CLINICAL-CRITERIA; RESPONSE RATES; PRIMARY-CARE;
D O I：
10.2217/pme-2020-0026
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim:Lynch Syndrome is associated with a significant risk of colorectal carcinoma (CRC) and other cancers. Universal tumor screening is a strategy to identify high-risk individuals by testing all CRC tumors for molecular features suggestive of Lynch Syndrome. Patient interest in screening and preferences for consent have been underexplored.Methods:A postal survey was administered to CRC patients in a Canadian province.Results:Most patients (81.4%) were willing to have tumors tested if universal tumor screening were available and were willing to discuss test results with family members and healthcare professionals. The majority (62.6%) preferred informed consent be obtained prior to screening.Conclusion:Patients were supportive of universal screening. They expected consent to be obtained, contrary to current practice across Canada and elsewhere.
引用
收藏
页码：373 / 387
页数：15
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