Universal tumor screening for lynch syndrome: perspectives of patients regarding willingness and informed consent

被引：6

作者：

Subramonian, Anusree ^{[1
]}

Smith, Doug

Dicks, Elizabeth ^{[1
]}

Dawson, Lesa ^{[2
,3
]}

Borgaonkar, Mark ^{[4
]}

Etchegary, Holly ^{[1
]}

机构：

[1] Mem Univ, Fac Med, Clin Epidemiol, St John, NF, Canada

[2] Mem Univ, Fac Med, Gynecol Oncol Womens Hlth & Genet, St John, NF, Canada

[3] Eastern Hlth, Womens Hlth & Genet, St John, NF, Canada

[4] Mem Univ, Fac Med, Gastroenterol, St John, NF, Canada

来源：

PERSONALIZED MEDICINE | 2020年 / 17卷 / 05期

关键词：

colorectal cancer; lynch syndrome; patient oriented research; reflex testing; universal tumor screening; REVISED BETHESDA GUIDELINES; GENETIC TESTING STRATEGIES; COLORECTAL-CANCER SYNDROME; MICROSATELLITE INSTABILITY; FAMILY COMMUNICATION; REDUCING MORBIDITY; COST-EFFECTIVENESS; CLINICAL-CRITERIA; RESPONSE RATES; PRIMARY-CARE;

D O I：

10.2217/pme-2020-0026

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim:Lynch Syndrome is associated with a significant risk of colorectal carcinoma (CRC) and other cancers. Universal tumor screening is a strategy to identify high-risk individuals by testing all CRC tumors for molecular features suggestive of Lynch Syndrome. Patient interest in screening and preferences for consent have been underexplored.Methods:A postal survey was administered to CRC patients in a Canadian province.Results:Most patients (81.4%) were willing to have tumors tested if universal tumor screening were available and were willing to discuss test results with family members and healthcare professionals. The majority (62.6%) preferred informed consent be obtained prior to screening.Conclusion:Patients were supportive of universal screening. They expected consent to be obtained, contrary to current practice across Canada and elsewhere.

引用

页码：373 / 387

页数：15

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