X-chromosome inactivation: new insights into cis and trans regulation

被引：114

作者：

Galupa, Rafael ^{[1
]}

Heard, Edith ^{[1
]}

机构：

[1] PSL Univ, Inst Curie, Mammalian Dev Epigenet Grp, CNRS UMR3215,INSERM U934, F-75005 Paris, France

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2015年 / 31卷

关键词：

LONG NONCODING RNA; XIST RNA; HISTONE H3; CHROMATIN-STRUCTURE; TSIX; MICE; PLURIPOTENCY; BINDING; TRANSCRIPTION; REACTIVATION;

D O I：

10.1016/j.gde.2015.04.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

X-chromosome inactivation (XCl) is a developmentally associated process that evolved in mammals to enable gene dosage compensation between XX and XY individuals. In placental mammals, it is triggered by the long noncoding RNA Xist, which is produced from a complex regulatory locus, the X-inactivation centre (Xic). Recent insights into the regulatory landscape of the Xic, including its partitioning into topological associating domains (TADs) and its genetic dissection, have important implications for the monoallelic regulation of Xist. Here, we present some of the latest studies on X inactivation with a special focus on the regulation of Xist, its various functions and the putative role of chromosome conformation in regulating the dynamics of this locus during development and differentiation.

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收藏

页码：57 / 66

页数：10

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