Liquid chromatography-tandem mass spectrometry method as the golden standard for therapeutic drug monitoring in renal transplant

被引：34
作者：
Aucella, Filippo [1 ]
Lauriola, Vincenzo [1 ]
Vecchione, Gennaro [2 ]
Tiscia, Giovanni Luca [2 ]
Grandone, Elvira [2 ]
机构：
[1] IRCCS, Nephrol & Dialysis Dept, I-71013 San Giovanni Rotondo, Foggia, Italy
[2] IRCCS, Thrombosis & Haemostasis Unit, I-71013 San Giovanni Rotondo, Foggia, Italy
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2013年 / 86卷
关键词：
Kidney transplantation; Immunosuppression; Therapeutic drug monitoring; Liquid chromatography; Mass spectrometry; TACROLIMUS CONCENTRATIONS; MS/MS METHOD; CYCLOSPORINE; BLOOD; EVEROLIMUS; IMMUNOASSAY; PERFORMANCE; QUANTIFICATION; EXTRACTION; REJECTION;
D O I：
10.1016/j.jpba.2013.08.001
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Kidney transplanted patients need immunosuppressant therapies. Therapeutic drug monitoring approaches produce the optimal clinical outcome is still under debate. This review details strength and limits of methods available: immunoassay and chromatography-based. Liquid chromatography with mass spectrometry detection is a major breakthrough in therapeutic drug monitoring of immunosuppressive agents and is considered as the method of choice in therapeutic drug monitoring (TDM) of immunosuppressants. Despite the initial high cost for the instrumentation, HPLC-MS is more cost effective than microparticle enzyme immunoassay. The main important features of LC-MS/MS methodology for immunosuppressive drugs are the shortened analysis time, an increased throughput, higher selectivity, specificity, and sensitivity, and low cost of analysis. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：123 / 126
页数：4
相关论文
共 49 条
[1]   RISK-FACTORS FOR CHRONIC REJECTION IN RENAL-ALLOGRAFT RECIPIENTS [J].
ALMOND, PS ;
MATAS, A ;
GILLINGHAM, K ;
DUNN, DL ;
PAYNE, WD ;
GORES, P ;
GRUESSNER, R ;
NAJARIAN, JS ;
FERGUSON ;
PAUL ;
SCHAFFER .
TRANSPLANTATION, 1993, 55 (04) :752-757
[2]  
[Anonymous], 2012, LANCET, V379, P1461, DOI 10.1016/S0140-6736(12)60613-8
[3]   Simultaneous determination of everolimus and cyclosporine concentrations by HPLC with ultraviolet detection [J].
Baldelli, S ;
Zenoni, S ;
Merlini, S ;
Perico, N ;
Cattaneo, D .
CLINICA CHIMICA ACTA, 2006, 364 (1-2) :354-358
[4]  
Bowers LD, 1998, CLIN CHEM, V44, P375
[5]   Liquid Chromatography-Tandem Mass Spectrometry or Automated Immunoassays: What Are the Future Trends in Therapeutic Drug Monitoring? [J].
Brandhorst, Gunnar ;
Oellerich, Michael ;
Maine, Gregory ;
Taylor, Paul ;
Veen, Gerhard ;
Wallemacq, Pierre .
CLINICAL CHEMISTRY, 2012, 58 (05) :821-825
[6]   Rapid simultaneous quantification of immunosuppressants in transplant patients by turbulent flow chromatography combined with tandem mass spectrometry [J].
Ceglarek, U ;
Lembcke, J ;
Fiedler, GM ;
Werner, M ;
Witzigmann, H ;
Hauss, JP ;
Thiery, J .
CLINICA CHIMICA ACTA, 2004, 346 (02) :181-190
[7]   Inclusion of MPA and in a rapid multi-drug LC-tandem mass spectrometric method for simultaneous determination of immunosuppressants [J].
Ceglarek, Uta ;
Casetta, Bruno ;
Lembeke, Jan ;
Baumann, Sven ;
Fiedler, Georg M. ;
Thiery, Joachim .
CLINICA CHIMICA ACTA, 2006, 373 (1-2) :168-171
[8]   Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants [J].
Christians, U ;
Jacobsen, W ;
Serkova, N ;
Benet, LZ ;
Vidal, C ;
Sewing, KF ;
Manns, MP ;
Kirchner, GI .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2000, 748 (01) :41-53
[9]   Mass spectrometry-based biochemical assays for enzymeinhibitor screening [J].
de Boer, Arjen R. ;
Lingeman, Henk ;
Niessen, Wilfried M. A. ;
Irth, Hubertus .
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2007, 26 (09) :867-883
[10]   Biochemical applications of mass spectrometry in pharmaceutical drug discovery [J].
Geoghegan, KF ;
Kelly, MA .
MASS SPECTROMETRY REVIEWS, 2005, 24 (03) :347-366
12345