Lipid Peroxidation and Transforming Growth Factor-β1 Levels in Gastric Cancer at Pathologic Stages

被引：4
作者：
Tuzun, Sefa [1 ]
Yucel, Ahmet Fikret [2 ]
Pergel, Ahmet [2 ]
Kemik, Ahu Sarbay [3 ]
Kemik, Ozgur [4 ]
机构：
[1] Haseki Training & Res Hosp, Clin Surg Clin 2, Istanbul, Turkey
[2] Recep Tayyip Erdogan Univ, Dept Surg, Fac Med, Rize, Turkey
[3] Istanbul Univ, Dept Biochem, Cerrahpasa Fac Med, Istanbul, Turkey
[4] Yuzuncu Yil Univ, Dept Surg, Fac Med, Van, Turkey
来源：
BALKAN MEDICAL JOURNAL | 2012年 / 29卷 / 03期
关键词：
Gastric cancer; lipid peroxidation; TGF-beta; 1; GROWTH-FACTOR-BETA; TGF-BETA; GENE-EXPRESSION; CELLS; ADENOCARCINOMA; TGF-BETA-1; RECEPTORS; ASSOCIATION; CARCINOMA; SURVIVAL;
D O I：
10.5152/balkanmedj.2012.026
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: High levels of TGF-beta 1 and enhanced TGF-beta 1 receptor signaling are related to the pathology of gastric cancer. This effect is caused by oxidative stress and lipid peroxidation products. The aim of this study was to investigate the levels of TGF-beta 1 and lipid peroxidation products in gastric cancer patients and their correlation with pathologic stage. Material and Methods: Lipid peroxidation products and TGF-beta 1 levels were studied in the serum samples of 50 gastric cancer patients and 18 control subjects. Results: HNE-protein adducts and TGF-beta 1 levels were significantly higher in T2, T3 and T4 gastric cancers than in either the T1 stage or controls (p<0.001). Pathologic stage was correlated with TGF-beta 1 levels (r=0.702, p<0.05). Conclusion: These markers production may contribute to tumor angiogenesis and aid in the prognosis of the gastric cancer.
引用
收藏
页码：273 / 276
页数：4
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