Comparison of ART outcome in patients with poor ovarian response according to POSEIDON criteria

被引:8
作者
Lee, Hyun Joo [1 ]
Noh, Hye Kyung [2 ]
Joo, Jong Kil [1 ]
机构
[1] Pusan Natl Univ, Biomed Res Inst, Dept Obstet & Gynecol, Sch Med,Pusan Natl Univ Hosp, 179 Gudeok Ro, Busan 49241, South Korea
[2] Mama Papa & Baby Hosp, Ulsan, South Korea
关键词
LIVE BIRTH; WOMEN; FERTILIZATION; STIMULATION;
D O I
10.1038/s41598-022-22859-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The aim of this study is to evaluate whether the patient-oriented strategies encompassing individualized oocyte number (POSEIDON) criteria can reflect the prognosis of controlled ovarian stimulation (COS) by comparing the results of assisted reproductive technologies (ART) between four POSEIDON and normal responder (NR) groups. In total, 225 patients were included in this retrospective observational study. The patients underwent various COS protocols and in vitro fertilization or intracytoplasmic sperm injection, followed by fresh or frozen embryo transfer. Based on their clinical and demographic data, patients were divided into four groups according to the POSEIDON classification, and their ART outcomes were evaluated. Statistical analyses were performed using R version 4.0.5, and a p-value of < 0.05 was considered significant. The NR group had the highest number of total oocytes retrieved and total embryos obtained, as well as the best ART outcome in terms of clinical pregnancy rate ([CPR], 47.6%). The POSEIDON groups 1 and 2 had better COS and ART outcomes than groups 3 and 4 (CPR, 22.6%, 22.1%, 16.7%, and 4.8% in groups 1-4, respectively); the patients in group 3 were younger than those in group 2 by definition, but their CPR was lower than that of patients in group 2. When comparing young and old women with low anti-Mullerian hormone (AMH) levels, the younger group (POSEIDON group 2) had better COS and ART outcomes than their older counterparts, especially POSEIDON group 4. A binary logistic regression adjusted for body mass index (BMI) comparing the ART outcomes of patients that did not get pregnant in the POSEIDON groups compared to the NR group showed odds ratios (ORs) (95% confidence interval) of 2.938 (1.496-5.768), 3.376 (1.848-6.167), 6.801 (2.740-16.881), and 20.497 (8.284-50.713) for groups 1, 2, 3, and 4, respectively. Ovarian reserve still seems to outweigh patients' age when predicting the ART outcomes of low-responder infertile women, as suggested by the results of POSEIDON groups 2 and 3. However, when there are no differences in ovarian reserve, as in POSEIDON groups 2 and 4, younger women with low AMH have a higher probability of pregnancy than their AMH-matched older counterparts.
引用
收藏
页数:7
相关论文
共 26 条
[1]   Cumulative live-birth, perinatal and obstetric outcomes for POSEIDON groups after IVF/ICSI cycles: a single-center retrospective study [J].
Abdullah, Raed K. ;
Liu, Nenghui ;
Zhao, Yuhao ;
Shuang, Yang ;
Shen, Zhang ;
Zeng, Hong ;
Wu, Jielei .
SCIENTIFIC REPORTS, 2020, 10 (01)
[2]   Novel Physiology and Definition of Poor Ovarian Response; Clinical Recommendations [J].
Abu-Musa, Antoine ;
Haahr, Thor ;
Humaidan, Peter .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (06)
[3]   Understanding Ovarian Hypo-Response to Exogenous Gonadotropin in Ovarian Stimulation and Its New Proposed Marker-The Follicle-To-Oocyte (FOI) Index [J].
Alviggi, Carlo ;
Conforti, Alessandro ;
Esteves, Sandro C. ;
Vallone, Roberta ;
Venturella, Roberta ;
Staiano, Sonia ;
Castaldo, Emanuele ;
Andersen, Claus Yding ;
De Placido, Giuseppe .
FRONTIERS IN ENDOCRINOLOGY, 2018, 9
[4]   A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept [J].
Alviggi, Carlo ;
Andersen, Claus Y. ;
Buehler, Klaus ;
Conforti, Alessandro ;
De Placido, Giuseppe ;
Esteves, Sandro C. ;
Fischer, Robert ;
Galliano, Daniela ;
Polyzos, Nikolaos P. ;
Sunkara, Sesh K. ;
Ubaldi, Filippo M. ;
Humaidan, Peter .
FERTILITY AND STERILITY, 2016, 105 (06) :1452-1453
[5]   Effect of Age and Morphology on Live Birth Rate After Cleavage Stage Embryo Transfer [J].
Awadalla, Michael ;
Vestal, Nicole ;
McGinnis, Lynda ;
Ahmady, Ali .
REPRODUCTIVE SCIENCES, 2021, 28 (01) :43-51
[6]   A validated model for predicting live birth after embryo transfer [J].
Awadalla, Michael S. ;
Bendikson, Kristin A. ;
Ho, Jacqueline R. ;
McGinnis, Lynda K. ;
Ahmady, Ali .
SCIENTIFIC REPORTS, 2021, 11 (01)
[7]   What Is the Best Regimen for Ovarian Stimulation of Poor Responders in ART/IVF? [J].
Blumenfeld, Zeev .
FRONTIERS IN ENDOCRINOLOGY, 2020, 11
[8]   Follicular Output Rate and Follicle-to-Oocyte Index of Low Prognosis Patients According to POSEIDON Criteria: A Retrospective Cohort Study of 32,128 Treatment Cycles [J].
Chen, Lijuan ;
Wang, Hui ;
Zhou, Hanying ;
Bai, Haiyan ;
Wang, Tao ;
Shi, Wenhao ;
Shi, Juanzi .
FRONTIERS IN ENDOCRINOLOGY, 2020, 11
[9]   POSEIDON classification and the proposed treatment options for groups 1 and 2: time to revisit? A retrospective analysis of 1425 ART cycles [J].
Chinta, Parimala ;
Antonisamy, Belavendra ;
Mangalaraj, Ann M. ;
Kunjummen, Aleyamma T. ;
Kamath, Mohan S. .
HUMAN REPRODUCTION OPEN, 2021, 2021 (01)
[10]   Early ovarian ageing: is a low number of oocytes harvested in young women associated with an earlier and increased risk of age-related diseases? [J].
Christensen, M. W. ;
Kesmodel, U. S. ;
Christensen, K. ;
Kirkegaard, K. ;
Ingerslev, H. J. .
HUMAN REPRODUCTION, 2020, 35 (10) :2375-2390