In vitro antiviral effect of flavonoid-rich extracts of Vitex polygama (Verbenaceae) against acyclovir-resistant herpes simplex virus type 1

被引：31
作者：
Gonçalves, JLS
Leitao, SG
Delle Monache, F
Miranda, MMFS
Santos, MGM
Romanos, MTV
Wigg, MD
机构：
[1] CCS, UFRJ, Inst Microbiol Prof Paulo Goes, BR-21941590 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, CCS, Fac Farm, Dept Prod Nat & Alimentos, Rio De Janeiro, Brazil
[3] Univ Cattolica Sacro Cuore, CNR, Ctr Chim Recettori, Ist Chim, Rome, Italy
来源：
PHYTOMEDICINE | 2001年 / 8卷 / 06期
关键词：
antiviral activity; virucidal; HEp-2; cells; acyclovir-resistant HSV-1; flavonoids; Vitex polygama; Verbenaceae;
D O I：
10.1078/S0944-7113(04)70069-0
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Extracts and fractions rich in flavonoids from fruits and leaves of Vitex polygama Cham. (Verbenaceae) were tested against acyclovir-resistant herpes simplex virus type 1 (ACV(R)-HSV-1). Both fruit and leaf extracts exhibited a dose-dependent antiviral activity. The extract from the leaves showed intracellular antiviral activity while the extract from the fruits had virucidal effect. A fraction from the ethyl actetate extract of the leaves inhibited virus propagation by blocking HEp-2 cell receptors.
引用
收藏
页码：477 / 480
页数：4
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