miR-15a and 16-1 Are Downregulated in CD4+ T Cells of Multiple Sclerosis Relapsing Patients

被引：52

作者：

Cetrulo Lorenzi, Julio Cesar ^{[1
,2
]}

Brum, Doralina G. ^{[3
]}

Zanette, Dalila L. ^{[1
,2
]}

Alves Souza, Alessandra de Paula ^{[2
,4
]}

Barbuzano, Fernanda Goncalves ^{[2
]}

dos Santos, Antonio Carlos ^{[5
]}

Barreira, Amilton Antunes ^{[3
]}

Silva, Wilson Araujo, Jr. ^{[1
,2
]}

机构：

[1] Univ Sao Paulo, Dept Genet, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil

[2] Natl Inst Sci & Technol Stem Cell & Cell Therapy, Ribeirao Preto, Brazil

[3] Univ Sao Paulo, Dept Neurosci, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil

[4] Univ Sao Paulo, Dept Immunol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil

[5] Univ Sao Paulo, Dept Internal Med, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2012年 / 122卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

apoptosis; BCL-2; lymphocytes; miRNAs; DISEASE-ACTIVITY; PERIPHERAL-BLOOD; APOPTOSIS; EXPRESSION; BCL-2; SURVIVAL;

D O I：

10.3109/00207454.2012.678444

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The pathology of relapsing-remitting multiple sclerosis (RR-MS) is largely attributed to activated autoreactive effector T lymphocytes. The influence of microRNAs on the immune response has been shown to occur in different pathways of lymphocyte differentiation and function. Here, the expression of the miRNAs miR-15a/161 in PBMC, CD4(+), and CD8(+) from RR-MS patients has been investigated. BCL2, a known miR-15a/16-1 target, has also been analyzed. The results have shown that miR-15a/16-1 is downregulated in CD4(+) T cells, whereas BCL2 is highly expressed in RR-MS patients only. Our data suggest that miR-15a/16-1 can also modulate the BCL2 gene expression in CD4(+) T cells from RR-MS patients, thereby affecting apoptosis processes.

引用

页码：466 / 471

页数：6

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