Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases

被引：64

作者：

Ma, Liang ^{[1
]}

Zhao, Yudan ^{[1
]}

Chen, Yuchen ^{[1
]}

Cheng, Biao ^{[2
]}

Peng, Anlin ^{[3
]}

Huang, Kun ^{[1
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Sch Pharm, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Dept Pharm, Tongji Med Coll, Wuhan 430014, Hubei, Peoples R China

[3] Third Hosp Wuhan, Dept Pharm, Wuhan 430060, Hubei, Peoples R China

[4] Wuhan Inst Biotechnol, Ctr Biomed Res, Wuhan 430075, Hubei, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2018年 / 819卷

关键词：

Amyloid; Neurodegenerative diseases; Animal model; C; elegans; Drug screening; Target identification; AMYOTROPHIC-LATERAL-SCLEROSIS; BETA-AMYLOID PEPTIDE; DOPAMINE NEURON DEGENERATION; ALPHA-SYNUCLEIN AGGREGATION; PRION-LIKE TRANSMISSION; C.-ELEGANS; PARKINSONS-DISEASE; OXIDATIVE STRESS; INDUCED TOXICITY; ANIMAL-MODELS;

D O I：

10.1016/j.ejphar.2017.11.051

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past decades, Caenorhabditis elegans (C. elegans) has been widely used as a model system because of its small size, transparent body, short generation time and lifespan (similar to 3 days and 3 weeks, respectively), completely sequenced genome and tractability to genetic manipulation. Protein misfolding and aggregation are key pathological features in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease and Amyotrophic lateral sclerosis. Animal models, including C. elegans, have been extensively used to discover and validate new drugs against neurodegenerative diseases. The well-defined and genetically tractable nervous system of C. elegans offers an effective model to explore basic mechanistic pathways of neurodegenerative diseases. Recent progress in high-throughput drug screening also provides a powerful approach for identifying chemical modulators of biological processes. Here, we summarize the latest progress of using C. elegans as a model system for target identification and drug screening in neurodegenerative diseases.

引用

页码：169 / 180

页数：12

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