Prognostic factors for survival in a Chinese population presenting with advanced non-small cell lung cancer with an emphasis on smoking status: A regional, single-institution, retrospective analysis of 4552 patients

被引:5
作者
Hu, Qiong [1 ,2 ]
Li, Bing [1 ,2 ]
Garfield, David [3 ]
Ren, Shengxiang [1 ]
Li, Aiwu [1 ]
Chen, Xiaoxia [1 ]
Zhou, CaiCun [1 ,2 ]
机构
[1] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Med Oncol, Shanghai 200433, Peoples R China
[2] Tongji Univ, Sch Med, Inst Canc, Shanghai 200433, Peoples R China
[3] ProMed Canc Ctr, Shanghai, Peoples R China
关键词
age; histology; non-small cell lung cancer; prognostic factor; smoking status; NEVER-SMOKERS; CIGARETTE-SMOKING; HISTOLOGY; ADENOCARCINOMA; CHEMOTHERAPY; EPIDEMIOLOGY; COMORBIDITY; OUTCOMES; IMPACT; SEX;
D O I
10.1111/j.1759-7714.2011.00099.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Lung cancer ranks as the top of cancer-related mortality in the world. Approximately 8590% of all lung cancer cases are non-small cell lung cancer (NSCLC). For advanced NSCLC patients, the five-year survival rate is less than 5%. Previous studies have attempted to determine prognostic factors, such as smoking status, gender, ethnicity, age, and histological type. However, the results are controversial and conflict. In this study, we investigated prognostic factors in a Chinese population presenting with advanced NSCLC. Methods: Medical records of patients with advanced NSCLC (AJCC Stage IIIB/IV) who received treatment at our institution were reviewed. Kaplan-Meier method and Cox Proportional Hazards model were performed in both univariate and multivariate analyses. Results: A total of 4552 patients were entered. Among them, 1320 (29.0%) were female, 2408 non-smokers (52.9%), and all had Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) = 0/1. Univariate analysis suggested that female gender (P < 0.001), adenocarcinoma histology (P < 0.001), age <70 (P < 0.001), and non-smoker status (P < 0.001) were associated with better survival. However, multivariate analysis demonstrated that age (hazard ratio [HR]= 1.173, 95% confidence interval [CI]: 1.0851.268, P < 0.001), smoking status (vs. non-smokers, HR = 1.212, 95% CI: 1.1231.308, P < 0.001), and histological type (non-adenocarcinoma vs. adenocarcinoma, HR = 1.104, 95% CI: 1.0311.181, P = 0.004), but not gender, were independent prognostic factors. Conclusions: Smoking status, age, and histological type are independent prognostic factors in Chinese NSCLC patients presenting with advanced disease. Non-smoking status is associated with better overall survival in Chinese NSCLC patients.
引用
收藏
页码:162 / 168
页数:7
相关论文
共 36 条
[1]   Age and comorbidity as independent prognostic factors in the treatment of non-small-cell lung cancer: A review of national cancer institute of Canada clinical trials group trials [J].
Asmis, Timothy R. ;
Ding, Keyue ;
Seymour, Lesley ;
Shepherd, Frances A. ;
Leighl, Natasha B. ;
Winton, Tim L. ;
Whitehead, Marlo ;
Spaans, Johanna N. ;
Graham, Barbara C. ;
Goss, Glenwood D. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (01) :54-59
[2]   Prognostic factors in non-small cell lung cancer - A decade of progress [J].
Brundage, MD ;
Davies, D ;
Mackillop, WJ .
CHEST, 2002, 122 (03) :1037-1057
[3]   Differences in epidemiology, histology, and survival between cigarette smokers and never-smokers who develop non-small cell lung cancer [J].
Bryant, Ayesha ;
Cerfolio, Robert James .
CHEST, 2007, 132 (01) :185-192
[4]   Influence of age, comorbidity and performance status on the choice of treatment for patients with non-small cell lung cancer; results of a population-based study [J].
de Rijke, JM ;
Schouten, LJ ;
ten Velde, GPM ;
Wanders, SL ;
Bollen, ECM ;
Lalisang, RI ;
van Dijck, JAAM ;
Kramer, GWP ;
van den Brandt, PA .
LUNG CANCER, 2004, 46 (02) :233-245
[5]   PROGNOSTIC FACTORS IN NONSMALL CELL LUNG-CANCER [J].
FELD, R ;
BORGES, M ;
GINER, V ;
GINSBERG, R ;
HARPER, P ;
KLASTERSKY, J ;
LACQUET, L ;
PAESMANS, M ;
PAYNE, D ;
ROSELL, R ;
SAUSE, W ;
SCULIER, JP ;
SHAW, E ;
SORENSEN, JB ;
SPLINTER, T ;
STAHEL, R ;
BUNN, P .
LUNG CANCER, 1994, 11 :S19-S23
[6]  
Greene F., 2002, AJCC cancer staging handbook: From the AJCC cancer staging manual, V6th
[7]  
Holli K, 1999, ACTA ONCOL, V38, P989
[8]   Sex-associated differences in non-small cell lung cancer in the new era: Is gender an independent prognostic factor? [J].
Hsu, Li-Han ;
Chu, Nei-Min ;
Liu, Chia-Chuan ;
Tsai, Stella Y. C. ;
You, Dong-Ling ;
Ko, Jen-Sheng ;
Lu, Mei-Chun ;
Feng, An-Chen .
LUNG CANCER, 2009, 66 (02) :262-267
[9]   Influence of histological type, smoking history and chemotherapy on survival after first-line therapy in patients with advanced non-small cell lung cancer [J].
Itaya, Toru ;
Yamaoto, Nobuyuki ;
Ando, Masahiko ;
Ebisawa, Masako ;
Nakamura, Yukiko ;
Murakami, Haruyasu ;
Asai, Gyo ;
Endo, Masahiro ;
Takahashi, Toshiaki .
CANCER SCIENCE, 2007, 98 (02) :226-230
[10]   Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis [J].
Khuder, SA .
LUNG CANCER, 2001, 31 (2-3) :139-148