Peptide-based carbon nanotubes for mitochondrial targeting

被引:53
作者
Battigelli, Alessia [1 ,2 ]
Russier, Julie [2 ]
Venturelli, Enrica [2 ]
Fabbro, Chiara [1 ,3 ]
Petronilli, Valeria [4 ,5 ]
Bernardi, Paolo [4 ,5 ]
Da Ros, Tatiana [1 ]
Prato, Maurizio [1 ]
Bianco, Alberto [2 ]
机构
[1] Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy
[2] CNRS, Inst Biol Mol & Cellulaire, Lab Immunopathol & Chim Therapeut, UPR 3572, F-67000 Strasbourg, France
[3] Univ Venice, Dept Mol Sci & Nanosyst, I-30123 Venice, Italy
[4] Univ Padua, CNR Inst Neurosci, I-35121 Padua, Italy
[5] Univ Padua, Dept Biomed Sci, I-35121 Padua, Italy
基金
英国生物技术与生命科学研究理事会;
关键词
PROTEIN IMPORT; DRUG-DELIVERY; GENE-THERAPY; PLASMID DNA; FUNCTIONALIZATION; DISEASES; CELLS; TRANSLOCATION; SYSTEM; MUSCLE;
D O I
10.1039/c3nr02694a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In the present study, we report the design and synthesis of peptide-based-multi-walled carbon nanotubes (MWCNTs) to target mitochondria. Targeting these intracellular organelles might open the way to develop alternative systems to address diseases related to genetic mutations in mitochondrial (mt)-DNA, by delivering therapeutic oligonucleotides. The first step towards mitochondrial delivery of this type of nucleic acid was to target MWCNTs to mitochondria by covalent functionalization with a well-known endogenous mitochondrial targeting sequence (MTS). The subcellular localization of the conjugates, which were fluorescently labeled, in murine RAW 264.7 macrophages and human HeLa cells was then studied using different microscopy techniques, such as wide-field epifluorescence microscopy, confocal laser scanning microscopy (CLSM) and transmission electron microscopy (TEM). The localization of the MTS-MWCNT conjugates into mitochondria was further confirmed by analyzing the isolated organelles using TEM.
引用
收藏
页码:9110 / 9117
页数:8
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