Evaluation of current sterility tests for human live viral vaccines

被引：1

作者：

Sasaki, T

Harasawa, R

Shintani, M

Fujiwara, H

Sasaki, Y

Horino, A

Kenri, T

Ishii, K

Chino, F

机构：

[1] UNIV TOKYO,FAC MED,ANIM CTR BIOMED RES,BUNKYO KU,TOKYO 113,JAPAN

[2] NIHON MILLIPORE LTD,ANALYT DIV,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

BIOLOGICALS | 1996年 / 24卷 / 01期

关键词：

D O I：

10.1006/biol.1996.0005

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Current sterility tests for human live viral vaccines were evaluated. A total of 43 lots of bulk suspension of live viral vaccines (measles, mumps, rubella and oral poliomyelitis) produced by six manufacturers in Japan were evaluated for bacteriostatic and mycoplasmastatic activities. Some of them showed fairly high bacteriostatic and mycoplasmastatic activities, due to antibiotics added during vaccine production. It was concluded that the current sterility test for mycoplasmas is not reliable to detect viable mycoplasmas in live viral vaccines. (C) 1996 The International Association of Biological Standardization

引用

页码：51 / 55

页数：5