Vanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of insulin-like activity

被引：55

作者：

Mendes, Isolda C. ^{[1
]}

Botion, Leida M. ^{[2
]}

Ferreira, Adaliene V. M. ^{[2
]}

Castellano, Eduardo E. ^{[3
]}

Beraldo, Heloisa ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Fisiol & Biofis, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Sao Paulo, Inst Fis, Sao Carlos, SP, Brazil

来源：

INORGANICA CHIMICA ACTA | 2009年 / 362卷 / 02期

关键词：

2-Pyridineformamide thiosemicarbazones; Vanadium; Insulin-like; METAL-COMPLEXES; 2-BENZOYLPYRIDINE-DERIVED THIOSEMICARBAZONES; CRYSTAL-STRUCTURE; MIMETIC ACTIVITY; COORDINATION; COPPER(II); N(4)-METHYLTHIOSEMICARBAZONE; N(4)-ETHYLTHIOSEMICARBAZONE;

D O I：

10.1016/j.ica.2008.04.029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of VOCl2 with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH) Cl-2] (1), [VO(H2Am4Me) Cl-2] center dot 1/2HCl (2), [VO(H2Am4Et) Cl-2] center dot HCl (3) and [VO(2Am4Ph) Cl] (4). Upon the dissolution of 1-4 in water, oxidation immediately occurs with the formation of [VO2(2Am4DH)] (5), [VO2(2Am4Me)] (6), [VO2(2Am4Et)] (7) and [VO2(2Am4Ph)] (8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5-8 inhibited glycerol release in a similar way to that observed with insulin but showed a low enhancing effect on glucose uptake by rat adipocytes. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：414 / 420

页数：7

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