New symmetric diisopropylphosphoryl-S-alkanedi yldiisothioureas. Investigations on their synthesis

被引：2

作者：

De Souza, MC

Ohara, AK

Araripe, DR

Dias, PD

Kuwata, JC

机构：

[1] Univ Fed Fluminense, Inst Quim, Dept Quim Organ, Niteroi, RJ, Brazil

[2] Univ Fed Fluminense, Inst Quim, Dept Quim Analit, Niteroi, RJ, Brazil

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1999年 / 148卷

关键词：

symmetric diisopropylphosphoryl S-alkanediyldiisothioureas; phosphorylation of S-alkanediyldiisothiourea; reaction of diisopropyl chlorophosphonate with S-alkanediyldiisothiourea;

D O I：

10.1080/10426509908037006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Symmetric dialkylphosphoryl-S-allcanediyldiisothioureas (RO)(2)P(O)NHC(=NH)S(CH2)(n) SC(=NH)NHP(O)(OR)(2) (I, R = isopropyl; n = 2-5) have potential coordination sites involving O, P, N and S as donors atoms. For their synthesis, common two-phase reactions between the corresponding diisothiourea derivatives and diisopropyl phosphonate were unsuccessful. Herein we describe a new synthesis for such compounds using diisopropyl chlorophosphonate. Two new bis-phosphorylated alkanediyldiisothioureas with increasing carbon chain (I; n = 3, n = 5) were prepared by this method.

引用

页码：143 / 148

页数：6

共 6 条

[1] Molecular recognition of protein-ligand complexes: Applications to drug design [J].