Do we understand the pathophysiology of GERD after sleeve gastrectomy?

被引：57

作者：

Felinska, Eleni ^{[1
]}

Billeter, Adrian ^{[1
]}

Nickel, Felix ^{[1
]}

Contin, Pietro ^{[1
]}

Berlth, Felix ^{[2
]}

Chand, Bipan ^{[3
]}

Grimminger, Peter ^{[4
]}

Mikami, Dean ^{[5
]}

Schoppmann, Sebastian F. ^{[6
]}

Mueller-Stich, Beat ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Gen Visceral & Transplant Surg, Neuenheimer Feld 110, D-69120 Heidelberg, Germany

[2] Univ Hosp Cologne, Dept Gen Visceral & Canc Surg, Cologne, Germany

[3] Loyola Univ, Dept Surg, Chicago, IL 60611 USA

[4] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Gen Visceral & Transplant Surg, Mainz, Germany

[5] Univ Hawaii, John A Burton Sch Med, Dept Surg, Honolulu, HI 96822 USA

[6] Med Univ Vienna, Div Gen Surg, Dept Surg, Vienna, Austria

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2020年 / 1482卷 / 01期

关键词：

gastroesophageal reflux; sleeve gastrectomy; bariatric surgery; morbid obesity; Y-GASTRIC BYPASS; GASTROESOPHAGEAL-REFLUX DISEASE; LOWER ESOPHAGEAL SPHINCTER; QUALITY-OF-LIFE; PROTON-PUMP INHIBITORS; INTENSIVE MEDICAL THERAPY; BARIATRIC SURGERY; WEIGHT-LOSS; BARRETTS-ESOPHAGUS; BALLOON DILATION;

D O I：

10.1111/nyas.14467

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gastroesophageal reflux disease (GERD), a prevalent problem among obese individuals, is strongly associated with obesity and weight loss. Hence, bariatric surgery effectively improves GERD for many patients. Depending on the type of bariatric procedure, however, surgery can also worsen or even cause a new onset of GERD. As a consequence, GERD remains a relevant problem for many bariatric patients, and especially those who have undergone sleeve gastrectomy (SG). Affected patients report not only a decrease in physical functioning but also suffer from mental and emotional problems, resulting in poorer social functioning. The pathomechanism of GERD after SG is most likely multifactorial and triggered by the interaction of anatomical, physiological, and physical factors. Contributing factors include the shape of the sleeve, the extent of injury to the lower esophageal sphincter, and the presence of hiatal hernia. In order to successfully treat post-sleeve gastrectomy GERD, the cause of the problem must first be identified. Therapeutic approaches include lifestyle changes, medication, interventional treatment, and/or revisional surgery.

引用

页码：26 / 35

页数：10

共 81 条

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