Anti-inflammatory and antinociceptive effects of hydroalcoholic extract from Pseudobombax marginatum inner bark from caatinga potiguar

被引:11
作者
Costa Paiva, Dayane Carla [1 ]
dos Santos, Cliomar Alves [2 ]
Diniz, Jaecio Carlos [1 ]
Viana, Francisco Arnaldo [1 ]
Thomazzi, Sara Maria [2 ]
Falcao, Dayseanne Araujo [1 ]
机构
[1] Univ Estado Rio Grande do Norte, BR-59633010 Mossoro, RN, Brazil
[2] Univ Fed Sergipe, BR-49100000 Sao Cristovao, SE, Brazil
关键词
Pseudobombax marginatum; Inflammation; Nociception;
D O I
10.1016/j.jep.2013.06.012
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Ethnopharmacological relevance: The Pseudobombax marginatum (St Hil) Rob., Malvaceae, is mentioned in ethnobotanical studies. It is used as anti-inflammatory, for ulcers and gastritis, and back pain. To evaluate anti-inflammatory and antinociceptive activities a hydroalcoholic extract (HE) from inner bark was prepared. Materials and methods: For the anti-inflammatory activity, carrageenan-induced paw edema and peritonitis models, and also myeloperoxidase assay were used. For the antinociceptiva activity acetic acid-induced writhing, hot plate and formalin tests were employed. Results: The HE extract exhibited an intense inhibition in carrageenan-induced edema model and also in myeloperoxidase activity at the doses of 100 and 300 mg/kg. The leukocyte migration into the peritoneal cavity was also inhibited at the doses of 30, 100 and 300 mg/kg. A similar profile was observed against acid-induced abdominal contortions and in formalin second phase test at the doses of 30 and 100 mg/kg, but this treatment did not affect the behavior of animals in the hot plate test. Conclusions: The experimental data of the HE from Pseudobombax marginatum show anti-inflammatory and antinociceptiva activities, confirming the indication from traditional medicine; however further studies are required to define and isolate the active anti-inflammatory and antinociceptiva components from this active specie. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:416 / 421
页数:6
相关论文
共 26 条
[1]   Survey of medicinal plants used in the region Northeast of Brazil [J].
Agra, Maria de Fatima ;
Silva, Kiriaki Nurit ;
Lima Diniz Basilio, Ionaldo Jose ;
de Freitas, Patricia Franca ;
Barbosa-Filho, Jose Maria .
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2008, 18 (03) :472-508
[2]   Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice [J].
Alves Rodrigues, Melissa Raboni ;
Sales Kanazawa, Luiz Kae ;
Machado das Neves, Thiago Louback ;
da Silva, Carla Francielle ;
Horst, Heros ;
Pizzolatti, Moacir Geraldo ;
Soares Santos, Adair Roberto ;
Baggio, Cristiane Hatsuko ;
de Paula Werner, Maria Fernanda .
JOURNAL OF ETHNOPHARMACOLOGY, 2012, 139 (02) :519-526
[3]   MEASUREMENT OF CUTANEOUS INFLAMMATION - ESTIMATION OF NEUTROPHIL CONTENT WITH AN ENZYME MARKER [J].
BRADLEY, PP ;
PRIEBAT, DA ;
CHRISTENSEN, RD ;
ROTHSTEIN, G .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1982, 78 (03) :206-209
[4]  
CAPAZ FR, 1981, ARCH INT PHARMACOD T, V251, P228
[5]   Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention [J].
Davies, Michael J. .
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2011, 48 (01) :8-19
[6]  
de Cruvinel W. M., 2010, REV BRAS REUMATOL, V50, P434, DOI DOI 10.1590/S0482-50042010000400008
[7]   Advances in ethnobotany research in Brazil. [J].
de Oliveira, Flavia Camargo ;
de Albuquerque, Ulysses Paulino ;
da Fonseca-Kruel, Viviane Stern ;
Hanazaki, Natalia .
ACTA BOTANICA BRASILICA, 2009, 23 (02) :590-605
[8]   Flavonoids: Old and new aspects of a class of natural therapeutic drugs [J].
Di Carlo, G ;
Mascolo, N ;
Izzo, AA ;
Capasso, F .
LIFE SCIENCES, 1999, 65 (04) :337-353
[9]   Plasticity: Implications for opioid and other pharmacological interventions in specific pain states [J].
Dickenson, AH .
BEHAVIORAL AND BRAIN SCIENCES, 1997, 20 (03) :392-+
[10]  
Duarte M.C., 2012, PSEUDOBOMBAX LISTA E