Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease

被引：11

作者：

Vesperman, Clayton J. ^{[1
]}

Wang, Rui ^{[1
,9
,10
]}

Schultz, Stephanie A. ^{[1
,7
,8
]}

Law, Lena L. ^{[1
]}

Dougherty, Ryan J. ^{[1
,4
]}

Ma, Yue ^{[1
]}

Oh, Jennifer M. ^{[1
]}

Edwards, Dorothy F. ^{[4
]}

Gallagher, Catherine L. ^{[1
,5
]}

Chin, Nathaniel A. ^{[1
]}

Asthana, Sanjay ^{[1
,2
]}

Hermann, Bruce P. ^{[1
,5
]}

Sager, Mark A. ^{[1
,3
]}

Johnson, Sterling C. ^{[1
,2
,3
]}

Cook, Dane B. ^{[4
,6
]}

Okonkwo, Ozioma C. ^{[1
,2
,3
]}

机构：

[1] Univ Wisconsin, Wisconsin Alzheimers Dis Res Ctr, Sch Med & Publ Hlth, Madison, WI USA

[2] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI USA

[3] Univ Wisconsin, Wisconsin Alzheimers Inst, Sch Med & Publ Hlth, Madison, WI USA

[4] Univ Wisconsin, Dept Kinesiol, Sch Educ, Madison, WI USA

[5] Univ Wisconsin, Dept Neurol, Sch Med & Publ Hlth, Madison, WI USA

[6] William S Middleton Mem Vet Adm Med Ctr, Res Serv, Madison, WI USA

[7] Univ Wisconsin, Dept Radiol, Sch Med & Publ Hlth, Madison, WI USA

[8] Washington Univ St Louis, Dept Radiol, Sch Med, St Louis, MO USA

[9] GIH, Swedish Sch Sport & Hlth Sci, Stockholm, Sweden

[10] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2022年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

aging; cognition; episodic memory; exercise test; humans; neuropsychological tests; WISCONSIN-REGISTRY; AGE; DECLINE; ADULTS;

D O I：

10.1002/dad2.12330

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionThis study examined the relationship between cardiorespiratory fitness (CRF) and longitudinal cognitive functioning in a cohort enriched with risk factors for Alzheimer's disease (AD). MethodsA total of 155 enrollees in the Wisconsin Registry for Alzheimer's Prevention completed repeat comprehensive neuropsychological evaluations that assessed six cognitive domains. Peak oxygen consumption (VO(2)peak) was the primary measure of CRF. Random effects regression was used to investigate the effect of CRF on cognitive trajectories. ResultsHigher CRF was associated with slower decline in the cognitive domains of verbal learning and memory (P < .01) and visual learning and memory (P < .042). Secondary analyses indicated that these effects were stronger among men than women, and for noncarriers of the apolipoprotein E epsilon 4 allele. DiscussionHigher CRF was associated with a slower rate of the decline in episodic memory that occurs as a natural consequence of aging in a cohort enriched with risk factors for AD.

引用

页数：9

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