The Biology of Recent Thymic Emigrants

被引:132
作者
Fink, Pamela J. [1 ]
机构
[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
来源
ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 | 2013年 / 31卷
关键词
post-thymic maturation; T cell development; T cell homeostasis; T-CELL HOMEOSTASIS; UNDERGO POSTTHYMIC MATURATION; PERIPHERAL LYMPHOID-TISSUES; BONE-MARROW-TRANSPLANTATION; EXCISION CIRCLE CONTENT; AGE-RELATED-CHANGES; TYROSINE KINASE 7; IMMUNE RECONSTITUTION; HIV-INFECTION; MATURE THYMOCYTES;
D O I
10.1146/annurev-immunol-032712-100010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The generation of the TCR alpha beta lineage of T cells occurs in the thymus through a series of orchestrated developmental events that result in a carefully selected population of CD4 or CD8 lineage-committed TCR+ thymocytes capable of recognizing foreign antigen in the context of self MHC. T cells first exit the thymus in a phenotypically and functionally immature state and require an approximately 3-week period of post-thymic maturation before transitioning into the mature T cell compartment. A greater understanding of recent thymic emigrant biology has come with the development of methods to exclusively identify and isolate this population for further characterization. I now review current knowledge about the phenotype and function of this key but understudied population of peripheral T cells.
引用
收藏
页码:31 / 50
页数:20
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