Prevalence and Characteristics of Sleep Apnea in Intensive Care Unit Survivors After SARS-CoV-2 Pneumonia

被引：4

作者：

Traore, Ibrahim ^{[1
]}

Eberst, Guillaume ^{[1
,2
,3
]}

Claude, Frederic ^{[1
]}

Laurent, Lucie ^{[1
]}

Meurisse, Aurelia ^{[2
,3
]}

Paget-Bailly, Sophie ^{[2
,3
]}

Roux-Claude, Pauline ^{[1
]}

Jacoulet, Pascale ^{[1
]}

Barnig, Cindy ^{[1
]}

Martarello, Rachel ^{[1
]}

Poirson, Bastien ^{[4
]}

Bouiller, Kevin ^{[5
]}

Chirouze, Catherine ^{[5
]}

Behr, Julien ^{[6
]}

Grillet, Franck ^{[6
]}

Ritter, Ophelie ^{[1
]}

Pili-Floury, Sebastien ^{[7
]}

Winiszewski, Hadrien ^{[8
]}

Samain, Emmanuel ^{[7
,9
]}

Capellier, Gilles ^{[8
,9
,10
]}

Westeel, Virginie ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Besancon, Resp Med Dept, Besancon, France

[2] Univ Hosp, Methodol & Qual Life Oncol Unit, Besancon, France

[3] Univ Franche Comte, UMR 1098, Besancon, France

[4] Univ Hosp Besancon, Dept Geriatr, Besancon, France

[5] Univ Hosp Besancon, Dept Infect Dis, Besancon, France

[6] Univ Hosp Besancon, Dept Radiol, Besancon, France

[7] Univ Hosp Besancon, Anesthesia & Intens Care Unit, Besancon, France

[8] Univ Hosp Besancon, Med Intens Care Unit, Besancon, France

[9] Univ Franche Comte, Res Unit EA3920, Besancon, France

[10] Monash Univ, Australian & New Zealand Intens Care Res Ctr, Dept Epidemiol & Prevent Med, Clayton, Australia

来源：

NATURE AND SCIENCE OF SLEEP | 2022年 / 14卷

关键词：

SARS-CoV-2; pneumonia; obstructive sleep apnea syndrome; intensive care unit; POTENTIAL ROLE; LUNG-VOLUME; WEIGHT-GAIN; QUESTIONNAIRE; INFECTION; DISORDERS; OBESITY; RISK; STOP;

D O I：

10.2147/NSS.S377946

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Sleep apnea (SA) was reported as possibly exacerbating symptoms of COVID-19, a disease induced by SARS-CoV-2 virus. The same comorbidities are common with both pathologies. This study aimed to estimate the prevalence, characteristics of SA and variation in AHI three months after severe COVID-19 requiring intensive care unit (ICU) admission.Methods: A prospective cohort of patients admitted to ICU for severe COVID-19 underwent an overnight home polygraphy 3 months after onset of symptoms, as part of a comprehensive follow-up program (pulmonary function tests, 6-minute walk tests and chest CT -scan). Patients with an apnea hypopnea index (AHI) >5 were considered as having SA. We performed a comparative descriptive analysis of 2 subgroups according to the existence, severity of SA and indication for effective SA treatment: patients with absent or mild SA (AHI <15) vs patients with moderate to severe SA (AHI >15).Results: Among 68 patients included, 62 (91%) had known comorbidities (34 hypertension, 21 obesity, 20 dyslipidemia, 16 type 2 diabetes). It has been observed a preexisting SA for 13 patients (19.1%). At 3 months, 62 patients (91%) had SA with 85.5% of obstructive events. Twenty-four patients had no or a mild SA (AHI <15) and 44 had moderate to severe SA (AHI >15). Ischemic heart disease exclusively affected the moderate to severe SA group. Except for thoracic CT-scan which revealed less honeycomb lesions, COVID-19 symptoms were more severe in the group with moderate to severe SA, requiring a longer curarization, more prone position sessions and more frequent tracheotomy.Conclusion: SA involved 91% of patients in our population at 3 months of severe COVID-19 and was mainly obstructive type. Although SA might be a risk factor as well as consequences of ICU care in severe COVID-19 infection, our results underline the importance of sleep explorations after an ICU stay for this disease.

引用

页码：2213 / 2225

页数：13