Fear-enhancing effects of septal oxytocin receptors

被引：169

作者：

Guzman, Yomayra F. ^{[1
]}

Tronson, Natalie C. ^{[1
,2
]}

Jovasevic, Vladimir ^{[1
]}

Sato, Keisuke ^{[3
]}

Guedea, Anita L. ^{[1
]}

Mizukami, Hiroaki ^{[4
]}

Nishimori, Katsuhiko ^{[3
]}

Radulovic, Jelena ^{[1
]}

机构：

[1] Northwestern Univ, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA

[2] Univ Michigan, Dept Psychol, Ann Arbor, MI USA

[3] Tohoku Univ, Grad Sch Agr Sci, Dept Mol & Cell Biol, Sendai, Miyagi 980, Japan

[4] Jichi Med Univ, Ctr Mol Med, Div Genet Therapeut, Shimotsuke, Tochigi, Japan

来源：

NATURE NEUROSCIENCE | 2013年 / 16卷 / 09期

基金：

美国国家卫生研究院;

关键词：

SOCIAL DEFEAT; MICE; STRESS; VASOPRESSIN; RELEASE; NEURONS; ANXIETY;

D O I：

10.1038/nn.3465

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic, prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently emerged. Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of Oxtr. These effects emerge after social defeat and require Oxtr specifically coupled to the extracellular signal-regulated protein kinase pathway.

引用

页码：1185 / U36

页数：5

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