The NMDA Agonist D-Cycloserine Facilitates Fear Memory Consolidation in Humans

被引：82

作者：

Kalisch, Raffael ^{[1
,2
,3
]}

Holt, Beatrice ^{[1
]}

Petrovic, Predrag ^{[1
]}

De Martino, Benedetto ^{[1
]}

Kloppel, Stefan ^{[1
,4
]}

Buchel, Christian ^{[2
,3
]}

Dolan, Raymond J. ^{[1
]}

机构：

[1] UCL, Funct Imaging Lab, Wellcome Dept Imaging Neurosci, London, England

[2] Neuroimage Nord, Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Inst Syst Neurosci, D-20246 Hamburg, Germany

[4] Univ Freiburg, Dept Psychiat & Psychotherapy, Freiburg, Germany

来源：

CEREBRAL CORTEX | 2009年 / 19卷 / 01期

基金：

英国惠康基金;

关键词：

CONDITIONED FEAR; HIPPOCAMPAL INACTIVATION; ELECTROLYTIC LESIONS; POTENTIATED STARTLE; RETROGRADE-AMNESIA; DORSAL HIPPOCAMPUS; EXPOSURE THERAPY; CONTROLLED-TRIAL; EXTINCTION; ACQUISITION;

D O I：

10.1093/cercor/bhn076

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycloserine (DCS) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (CS) at a memory test performed 72 h later. DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans.

引用

页码：187 / 196

页数：10