RUbioSeq plus : An Application that Executes Parallelized Pipelines to Analyse Next-Generation Sequencing Data

被引：0

作者：

Rubio-Camarillo, Miriam ^{[1
]}

Lopez-Fernandez, Hugo ^{[2
,3
]}

Gomez-Lopez, Gonzalo ^{[1
]}

Carro, Angel

Maria Fernandez, Jose ^{[4
]}

Fdez-Riverola, Florentino ^{[2
,3
]}

Glez-Pena, Daniel ^{[2
,3
]}

Pisano, David G. ^{[1
]}

机构：

[1] Spanish Natl Canc Res Ctr CNIO, Bioinformat Unit UBio, Struct Biol & Biocomp Programme, Madrid, Spain

[2] Univ Vigo, ESEI Escuela Super Ingn Informat, Edificio Politecn,Campus Univ Lagoas S-N, Orense 32004, Spain

[3] IBIV, Vigo, Spain

[4] Spanish Natl Canc Res Ctr CNIO, Struct Computat Biol Grp, Struct Biol & BioComp Programme, 3rd Melchor Fernandez Almagro St, Madrid 28029, Spain

来源：

10TH INTERNATIONAL CONFERENCE ON PRACTICAL APPLICATIONS OF COMPUTATIONAL BIOLOGY & BIOINFORMATICS | 2016年 / 477卷

关键词：

NGS analysis; Parallelized workflows; Whole-genome; Variant calling; ChIPSeq; Bisulfite-Seq; CNV; HPC; SGE; CHIP-SEQ; ALIGNMENT; GENOMES; MODEL;

D O I：

10.1007/978-3-319-40126-3_15

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

To facilitate routine analysis and to improve the reproducibility of the results, next-generation sequencing analysis requires intuitive, efficient and integrated data processing pipelines. Here, we present RUbioSeq+, a multiplatform application that incorporates a suite of automated and parallelized workflows to analyse NGS data. The software supports DNA-seq (single-nucleotide and copy number variation analyses) as well as for bisulfite-seq and ChIP-seq workflows. RUbioSeq+ supports parallelized and multithreaded execution, and its interactive graphical user interface facilitates its use by both biomedical researchers and bioinformaticians. Results generated by our software have been experimentally validated and accepted for publication. RUbioSeq+ is free and open to all users at http://rubioseq.bioinfo.cnio.es/.

引用

页码：141 / 149

页数：9

共 21 条

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