Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment

被引：71
作者：
Ma, Zhe [1 ,2 ]
Fan, Yuqi [2 ,3 ]
Wu, Yumei [1 ,2 ]
Kebebe, Dereje [1 ,2 ,4 ]
Zhang, Bing [1 ,2 ]
Lu, Peng [1 ,2 ]
Pi, Jiaxin [1 ,2 ]
Liu, Zhidong [1 ,2 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Minist Educ, Engn Res Ctr Modern Chinese Med Discovery & Prepa, Tianjin 300193, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 300193, Peoples R China
[3] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 300193, Peoples R China
[4] Jimma Univ, Inst Hlth Sci, Sch Pharm, Jimma, Ethiopia
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2019年 / 14卷
基金：
中国国家自然科学基金;
关键词：
cancer; codelivery; combination therapy; nanotargeted drug-delivery system; tumor targeting; TCM; NF-KAPPA-B; ACID INHIBITS PROLIFERATION; LOW-DENSITY-LIPOPROTEIN; CELLS IN-VITRO; OVERCOME MULTIDRUG-RESISTANCE; POLYMER HYBRID NANOPARTICLES; REDOX-SENSITIVE MICELLES; GASTRIC-CANCER CELLS; CO-DELIVERY; BREAST-CANCER;
D O I：
10.2147/IJN.S197889
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Cancer is a major public health problem, and is now the world's leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nano-targeted drug-delivery systems have remarkable advantages and allow the development of TCM-combination therapies by systematically controlling drug release and delivering drugs to solid tumors. In this review, the anticancer activity of TCM compounds is introduced. The combined use of TCM for antitumor treatment is analyzed and summarized. These combination therapies, using a single nanocarrier system, namely codelivery, are analyzed, issues that require attention are determined, and future perspectives are identified. We carried out a systematic review of >280 studies published in PubMed since 1985 (no patents involved), in order to provide a few basic considerations in terms of the design principles and management of targeted nanotechnology-based TCM-combination therapies.
引用
收藏
页码：2029 / 2053
页数：25
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