Triterpenoid saponins from Clematis tangutica and their cardioprotective activities

被引：26

作者：

Zhang, Wei ^{[1
]}

Wang, Xiaoyang ^{[1
]}

Tang, Haifeng ^{[1
,2
]}

Wang, Minchang ^{[3
]}

Ji, Lanju ^{[4
]}

Wen, Aidong ^{[1
]}

Wang, Jianbo ^{[2
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Inst Mat Med, Sch Pharm, Xian 710032, Peoples R China

[3] Xian Modern Chem Res Inst, Nucl Magnet Resonance Ctr, Xian 710065, Peoples R China

[4] Qinghai Yi Xin Pharmaceut Co Ltd, Xining 810003, Peoples R China

来源：

FITOTERAPIA | 2013年 / 84卷

基金：

中国国家自然科学基金;

关键词：

Clematis tangutica; Ranunculaceae; Triterpenoid saponin; Cardioprotective;

D O I：

10.1016/j.fitote.2012.12.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phytochemical investigation of the whole plants of Clematis tangutica led to the isolation of three new triterpenoid saponins (1-3), together with four known saponins (4-7). Their structures were determined by extensive spectral analysis and chemical evidences. Compounds 1-7 were evaluated for their cardioprotective activities in cardiomyocytes anoxia/reoxygenation (A/R) model. The results showed that those saponins exhibited cardioprotective effects by decreasing the levels of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH). (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：326 / 331

页数：6

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