Effects of neferine on CCL5 and CCR5 expression in SCG of type 2 diabetic rats

被引：29

作者：

Li, Guilin ^{[1
]}

Xu, Hong ^{[1
]}

Zhu, Shuanghua ^{[2
]}

Xu, Wenyuan ^{[3
]}

Qin, Shulan ^{[4
]}

Liu, Shuangmei ^{[1
]}

Tu, Guihua ^{[1
]}

Peng, Haiying ^{[1
]}

Qiu, Shuyi ^{[1
]}

Yu, Shicheng ^{[1
]}

Zhu, Qicheng ^{[1
]}

Fan, Bo ^{[1
]}

Zheng, Chaoran ^{[1
]}

Li, Guodong ^{[1
]}

Liang, Shangdong ^{[1
,5
]}

机构：

[1] Dept Physiol, Nanchang 330006, Jiangxi, Peoples R China

[2] Dept Clin Med 0 6 Class 2011 Grade, Nanchang 330006, Jiangxi, Peoples R China

[3] First Affiliated Hosp, Dept Neurol, Nanchang 330006, Jiangxi, Peoples R China

[4] Nanchang Univ, Affiliated Hosp 2, Coll Med, Endocrine Dept, Nanchang 330006, Jiangxi, Peoples R China

[5] Nanchang Univ, Inst Life Sci, Nanchang 330006, Jiangxi, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2013年 / 90卷

基金：

中国国家自然科学基金;

关键词：

Type; 2; diabetes; CCL5; CCR5; Neferine; Superior cervical ganglion; CHEMOKINE RECEPTORS; MOUSE MODEL; INFLAMMATION; PROLIFERATION; ACTIVATION; CHANNEL; IMPACT; CELLS;

D O I：

10.1016/j.brainresbull.2012.10.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chemokines and their receptors have the key role in inflammatory responses. The phenomenon of low grade inflammation is associated with the development of type 2 diabetes. Postprandial hyperglycemia increases the systemic inflammatory responses, which promotes the development of type 2 diabetic associating autonomic nervous injuries or cardiovascular disease. Neferine is a bisbenzylisoquinline alkaloid isolated from a Chinese medicinal herb. The objectives of this study will examine the CCL5 and CCR5 expression in the superior cervical ganglion (SCG) of type 2 diabetic rats. The effects of neferine on the expression of CCL5 and CCR5 mRNA and protein in the superior cervical ganglion (SCG) of type 2 diabetic rats will also be observed. The studies showed that in type 2 diabetic rats, body weight, blood pressure, heart rates, fasting blood glucose, insulin, total cholesterol and triglyceride were enhanced and high density lipoprotein was decreased, and CCL5 and CCR5 expression levels in the SCG of type 2 diabetic rats were up-regulated. In type 2 diabetic rats treated with neferine, body weight, blood pressure, fasting blood glucose, insulin, total cholesterol and triglyceride were decreased and high density lipoprotein was increased. The elevated expressions of CCL5 and CCR5 in SCG were decreased after type 2 diabetic rats treated with neferine. The motor nerve conduction velocity (MNCV) in diabetic rats treated with neferine group showed a significantly increment in comparison with that in type 2 diabetic group. Neferine can decrease the expression of CCL5 and CCR5 in the SCG and reduce the SCG neuronal signaling mediated by CCL5 and CCR5 in regulating diabetic cardiovascular autonomic complications. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：79 / 87

页数：9

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